Title: Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha.
Authors: Bourguet, William; Ruff, Marc
Abstract: Discusses the study which analyzed the crystal structure of ligand-binding domain (LBD) of human retinoid receptor, RXR-alpha for 9-cis retinoic acid. Dimeric packing of fold of anatiparallel alpha-helical sandwich; Homodimerization of RXR-alpha and LBD; Interaction of 9-cis retinoic acid with transactivation function AF-2; Prototype structure of fold.
Subjects: LIGAND binding (Biochemistry); RECEPTOR-ligand complexes; RETINOIDS
Publication: Nature, 1995, Vol 375, Issue 6530, p377
ISSN: 0028-0836
Publication type: Academic Journal
DOI: 10.1038/375377a0

Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha.

Bourguet, William; Ruff, Marc