Results
Title

A potent peptidomimetic inhibitor of HSV ribonucleotide deuctase with antiviral activity in vivo.

Authors

Liuzzi, Michel; Deziel, Robert

Abstract

Presents a study on potent peptidomimetic inhibitor (BILD 1263) of herpes simplex viruses (HSV) ribonucleotide reductase (RNRs). Antiviral activity of BILD 1263; Structure of HSV RNR sub-unit-association inhibitors; Effect of BILD 1263 on HSV replication and cell viability in serum-starved cell; Effect of topical BILD 1263 on HSV-1-induced ocular disease in mice.

Subjects

CHEMICAL inhibitors; HERPES simplex virus; RIBONUCLEOSIDE diphosphate reductase

Publication

Nature, 1994, Vol 372, Issue 6507, p695

ISSN

0028-0836

Publication type

Academic Journal

DOI

10.1038/372695a0