Results
Title

Efficient translation of prokaryotic mRNAs in a eukaryotic cell-free system requires addition of a cap structure.

Authors

Paterson, Bruce M.; Rosenberg, Martin

Abstract

In this and the accompanying paper we demonstrate that certain prokaryotic mRNAs, when modified at their 5′-termini with a cap structure, are translated in a eukaryotic cell-free protein synthesising system as efficiently as, or more efficiently than, eukaryotic mRNAs. Apparently, the prokaryotic mRNA contains all the information necessary for efficient recognition and initiation by eukaryotic translational components, except for the cap structure.

Publication

Nature, 1979, Vol 279, Issue 5715, p692

ISSN

0028-0836

Publication type

Academic Journal

DOI

10.1038/279692a0