Results
Title

Some cytokine profiles of T-helper cells in lesions of advanced periodontitis.

Authors

Berglundh, Tord; Liljenberg, Birgitta; Lindhe, Jan

Abstract

Abstract Objective: The aim of the present study was to analyze some cytokine profiles of T-helper cells in periodontitis lesions. Material and methods: 22 adult patients (7 females and 15 males, aged 24–66 years) with advanced and generalized chronic periodontitis were recruited. Clinical and radiographical characteristics of periodontal disease was assessed. From each patient a gingival biopsy was obtained from one randomly selected diseased interproximal site. The soft tissue sample was prepared for immunohistochemical analysis. Double staining was performed to detect cells positive for both the CD4 marker and different cytokines, i.e. interleukin (IL)-2, IL-4, IL-6 and interferon-gamma (IFN-γ). Results: The lesions in advanced periodontitis contained similar proportions of cells positive for the different cytokine markers examined. In addition, the number of cells expressing cytokine profiles for either T helper-1 (IFN-γ IL-2) or T helper-2 (IL-4 IL-6) was similar. Conclusion: It is suggested that the lesions of periodontitis are regulated by a combined Th-1 and Th-2 function.

Subjects

PERIODONTITIS; T cells; DIAGNOSTIC immunohistochemistry; CYTOKINES

Publication

Journal of Clinical Periodontology, 2002, Vol 29, Issue 8, p705

ISSN

0303-6979

Publication type

Academic Journal

DOI

10.1034/j.1600-051X.2002.290807.x