Works matching DE "UBIQUITIN"

Results: 5000

The Emerging Role and Mechanism of E2/E3 Hybrid Enzyme UBE2O in Human Diseases.

Published in:

Biomedicines, 2025, v. 13, n. 5, p. 1082, doi. 10.3390/biomedicines13051082

By:

Cheng, Qian;
Li, Zuyin;
Li, Yongjian;
Chen, Lei;
Chen, Dingbao;
Zhu, Jiye

Publication type:

Article

Non-Redundant Essential Roles of Proteasomal Ubiquitin Receptors Rpn10 and Rpn13 in Germ Cell Formation and Fertility.

Published in:

Cells (2073-4409), 2025, v. 14, n. 10, p. 696, doi. 10.3390/cells14100696

By:

Yue, Wan-Yu;
Zhang, Yi;
Jiang, Tian-Xia;
Qiu, Xiao-Bo

Publication type:

Article

Histone monoubiquitination by Clock-Bmal1 complex marks Per1 and Per2 genes for circadian feedback.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 10, p. 759, doi. 10.1038/nsmb.3076

By:

Tamayo, Alfred G;
Duong, Hao A;
Robles, Maria S;
Mann, Matthias;
Weitz, Charles J

Publication type:

Article

Structural basis for the RING-catalyzed synthesis of K63-linked ubiquitin chains.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 8, p. 597, doi. 10.1038/nsmb.3052

By:

Branigan, Emma;
Plechanovová, Anna;
Jaffray, Ellis G;
Naismith, James H;
Hay, Ronald T

Publication type:

Article

Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specificity.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 3, p. 222, doi. 10.1038/nsmb.2970

By:

Sato, Yusuke;
Goto, Eiji;
Shibata, Yuri;
Kubota, Yuji;
Yamagata, Atsushi;
Goto-Ito, Sakurako;
Kubota, Keiko;
Inoue, Jun-ichiro;
Takekawa, Mutsuhiro;
Tokunaga, Fuminori;
Fukai, Shuya

Publication type:

Article

Released from the chains of death.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 3, p. 184, doi. 10.1038/nsmb.2986

By:

Ghosh, Shubhendu

Publication type:

Article

Structural basis for interaction of a cotranslational chaperone with the eukaryotic ribosome.

Published in:

Nature Structural & Molecular Biology, 2014, v. 21, n. 12, p. 1042, doi. 10.1038/nsmb.2908

By:

Zhang, Yixiao;
Ma, Chengying;
Yuan, Yi;
Zhu, Jing;
Li, Ningning;
Chen, Chu;
Wu, Shan;
Yu, Li;
Lei, Jianlin;
Gao, Ning

Publication type:

Article

Ubiquitin sets the timer: impacts on aging and longevity.

Published in:

Nature Structural & Molecular Biology, 2014, v. 21, n. 4, p. 290, doi. 10.1038/nsmb.2806

By:

Kevei, Éva;
Hoppe, Thorsten

Publication type:

Article

Structure of the Rpn11-Rpn8 dimer reveals mechanisms of substrate deubiquitination during proteasomal degradation.

Published in:

Nature Structural & Molecular Biology, 2014, v. 21, n. 3, p. 220, doi. 10.1038/nsmb.2771

By:

Worden, Evan J;
Padovani, Chris;
Martin, Andreas

Publication type:

Article

E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 9, p. 1033, doi. 10.1038/nsmb.2655

By:

Wiener, Reuven;
DiBello, Anthony T;
Lombardi, Patrick M;
Guzzo, Catherine M;
Zhang, Xiangbin;
Matunis, Michael J;
Wolberger, Cynthia

Publication type:

Article

Essentiality of a non-RING element in priming donor ubiquitin for catalysis by a monomeric E3.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 8, p. 982, doi. 10.1038/nsmb.2621

By:

Dou, Hao;
Buetow, Lori;
Sibbet, Gary J;
Cameron, Kenneth;
Huang, Danny T

Publication type:

Article

Assembly, analysis and architecture of atypical ubiquitin chains.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 5, p. 555, doi. 10.1038/nsmb.2547

By:

Hospenthal, Manuela K;
Freund, Stefan M V;
Komander, David

Publication type:

Article

DUBs redox.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 4, p. 411, doi. 10.1038/nsmb.2560

By:

Larochelle, Stéphane

Publication type:

Article

Atg12-Atg5 conjugate enhances E2 activity of Atg3 by rearranging its catalytic site.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 4, p. 433, doi. 10.1038/nsmb.2527

By:

Sakoh-Nakatogawa, Machiko;
Matoba, Kazuaki;
Asai, Eri;
Kirisako, Hiromi;
Ishii, Junko;
Noda, Nobuo N;
Inagaki, Fuyuhiko;
Nakatogawa, Hitoshi;
Ohsumi, Yoshinori

Publication type:

Article

Sequential primed kinases create a damage-responsive phosphodegron on Eco1.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 2, p. 194, doi. 10.1038/nsmb.2478

By:

Lyons, Nicholas A;
Fonslow, Bryan R;
Diedrich, Jolene K;
Yates, John R;
Morgan, David O

Publication type:

Article

Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7-Atg3 and Atg7-Atg10 structures.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 12, p. 1242, doi. 10.1038/nsmb.2415

By:

Kaiser, Stephen E;
Mao, Kai;
Taherbhoy, Asad M;
Yu, Shanshan;
Olszewski, Jennifer L;
Duda, David M;
Kurinov, Igor;
Deng, Alan;
Fenn, Timothy D;
Klionsky, Daniel J;
Schulman, Brenda A

Publication type:

Article

Noncanonical recognition and UBL loading of distinct E2s by autophagy-essential Atg7.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 12, p. 1250, doi. 10.1038/nsmb.2451

By:

Yamaguchi, Masaya;
Matoba, Kazuaki;
Sawada, Ryoko;
Fujioka, Yuko;
Nakatogawa, Hitoshi;
Yamamoto, Hayashi;
Kobashigawa, Yoshihiro;
Hoshida, Hisashi;
Akada, Rinji;
Ohsumi, Yoshinori;
Noda, Nobuo N;
Inagaki, Fuyuhiko

Publication type:

Article

DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 11, p. 1093, doi. 10.1038/nsmb.2394

By:

Davis, Emily J;
Lachaud, Christophe;
Appleton, Paul;
Macartney, Thomas J;
Näthke, Inke;
Rouse, John

Publication type:

Article

Making the cut: intramembrane cleavage by a rhomboid protease promotes ERAD.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 10, p. 979, doi. 10.1038/nsmb.2398

By:

Greenblatt, Ethan J;
Olzmann, James A;
Kopito, Ron R

Publication type:

Article

BIRC7-E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 9, p. 876, doi. 10.1038/nsmb.2379

By:

Dou, Hao;
Buetow, Lori;
Sibbet, Gary J;
Cameron, Kenneth;
Huang, Danny T

Publication type:

Article

Inhibiting E2s.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 3, p. 267, doi. 10.1038/nsmb.2264

By:

Mason, Steve

Publication type:

Article

ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 3, p. 283, doi. 10.1038/nsmb.2217

By:

Kim, Myoung Ok;
Kim, Sung-Hyun;
Cho, Yong-Yeon;
Nadas, Janos;
Jeong, Chul-Ho;
Yao, Ke;
Kim, Dong Joon;
Yu, Dong-Hoon;
Keum, Young-Sam;
Lee, Kun-Yeong;
Huang, Zunnan;
Bode, Ann M;
Dong, Zigang

Publication type:

Article

Phosphorylation-dependent activity of the deubiquitinase DUBA.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 2, p. 171, doi. 10.1038/nsmb.2206

By:

Huang, Oscar W;
Ma, Xiaolei;
Yin, JianPing;
Flinders, Jeremy;
Maurer, Till;
Kayagaki, Nobuhiko;
Phung, Qui;
Bosanac, Ivan;
Arnott, David;
Dixit, Vishva M;
Hymowitz, Sarah G;
Starovasnik, Melissa A;
Cochran, Andrea G

Publication type:

Article

The E3 ligase RNF8 regulates KU80 removal and NHEJ repair.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 2, p. 201, doi. 10.1038/nsmb.2211

By:

Feng, Lin;
Chen, Junjie

Publication type:

Article

Tumor-suppressive Smurf.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 2, p. 135, doi. 10.1038/nsmb.2248

By:

Mason, Steve

Publication type:

Article

An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 1, p. 62, doi. 10.1038/nsmb.2169

By:

Licchesi, Julien D F;
Mieszczanek, Juliusz;
Mevissen, Tycho E T;
Rutherford, Trevor J;
Akutsu, Masato;
Virdee, Satpal;
Oualid, Farid El;
Chin, Jason W;
Ovaa, Huib;
Bienz, Mariann;
Komander, David

Publication type:

Article

Fluorescent fusion protein knockout mediated by anti-GFP nanobody.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 1, p. 117, doi. 10.1038/nsmb.2180

By:

Caussinus, Emmanuel;
Kanca, Oguz;
Affolter, Markus

Publication type:

Article

Mechanism of ubiquitylation by dimeric RING ligase RNF4.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 9, p. 1052, doi. 10.1038/nsmb.2108

By:

Plechanovová, Anna;
Jaffray, Ellis G.;
McMahon, Stephen A.;
Johnson, Kenneth A.;
Navrátilová, Iva;
Naismith, James H.;
Hay, Ronald T.

Publication type:

Article

Chfr and RNF8 synergistically regulate ATM activation.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 7, p. 761, doi. 10.1038/nsmb.2078

By:

Jiaxue Wu;
Yibin Chen;
Lin-Yu Lu;
Yipin Wu;
Paulsen, Michelle T.;
Ljungman, Mats;
Ferguson, David O.;
Xiaochun Yu

Publication type:

Article

A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 8, p. 947, doi. 10.1038/nsmb.2086

By:

Calabrese, Matthew F.;
Scott, Daniel C.;
Duda, David M.;
Grace, Christy R. R.;
Kurinov, Igor;
Kriwacki, Richard W.;
Schulman, Brenda A.

Publication type:

Article

Conformational flexibility and rotation of the RING domain in activation of cullin-RING ligases.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 8, p. 863, doi. 10.1038/nsmb.2117

By:

Rahighi, Simin;
Dikic, Ivan

Publication type:

Article

Constructing and decoding unconventional ubiquitin chains.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 5, p. 520, doi. 10.1038/nsmb.2066

By:

Behrends, Christian;
Harper, J. Wade

Publication type:

Article

Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 1, p. 6, doi. 10.1038/nsmb.1979

By:

Buschhorn, Bettina A;
Petzold, Georg;
Galova, Marta;
Dube, Prakash;
Kraft, Claudine;
Herzog, Franz;
Stark, Holger;
Peters, Jan-Michael

Publication type:

Article

Binding-induced folding of prokaryotic ubiquitin-like protein on the Mycobacterium proteasomal ATPase targets substrates for degradation.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 11, p. 1352, doi. 10.1038/nsmb.1918

By:

Tao Wang;
Darwin, K. Heran;
Huilin Li

Publication type:

Article

Structural basis of substrate recognition and specificity in the N-end rule pathway.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 10, p. 1182, doi. 10.1038/nsmb.1894

By:

Matta-Camacho, Edna;
Kozlov, Guennadi;
Li, Flora F.;
Gehring, Kalle

Publication type:

Article

The molecular principles of N-end rule recognition.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 10, p. 1164, doi. 10.1038/nsmb1010-1164

By:

Sriram, Shashikanth M.;
Yong Tae Kwon

Publication type:

Article

Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 10, p. 1175, doi. 10.1038/nsmb.1907

By:

Woo Suk Choi;
Byung-Cheon Jeong;
Yoo Jin Joo;
Myeong-Ryeol Lee;
Joon Kim;
Eck, Michael J.;
Hyun Kyu Song

Publication type:

Article

Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 8, p. 939, doi. 10.1038/nsmb.1873

By:

Bremm, Anja;
Freund, Stefan M. V.;
Komander, David

Publication type:

Article

Research highlights.

Published in:: Nature Structural & Molecular Biology, 2010, v. 17, n. 1, p. 4, doi. 10.1038/nsmb0110-4
Publication type:: Article

A promiscuous α-helical motif anchors viral hijackers and substrate receptors to the CUL4–DDB1 ubiquitin ligase machinery.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 1, p. 105, doi. 10.1038/nsmb.1719

By:

Ti Li;
Robert, Eva I.;
van Breugel, Pieter C.;
Strubin, Michel;
Ning Zheng

Publication type:

Article

Ubiquitin linkages make a difference.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 12, p. 1209, doi. 10.1038/nsmb1209-1209

By:

Dikic, Ivan;
Dötsch, Volker

Publication type:

Article

Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 12, p. 1328, doi. 10.1038/nsmb.1731

By:

Kulathu, Yogesh;
Akutsu, Masato;
Bremm, Anja;
Hofmann, Kay;
Komander, David

Publication type:

Article

Research highlights.

Published in:: Nature Structural & Molecular Biology, 2009, v. 16, n. 12, p. 1211, doi. 10.1038/nsmb1209-1211
Publication type:: Article

Research highlights.

Published in:: 2009
Publication type:: Abstract

Insights into anaphase promoting complex TPR subdomain assembly from a CDC26–APC6 structure.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 9, p. 987, doi. 10.1038/nsmb.1645

By:

Wang, Jin;
Dye, Billy T.;
Rajashankar, Kanagalaghatta R;
Kurinov, Igor;
Schulman, Brenda A.

Publication type:

Article

A molecular basis for phosphorylation-dependent SUMO conjugation by the E2 UBC9.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 9, p. 945, doi. 10.1038/nsmb.1648

By:

Mohideen, Firaz;
Capili, Allan D.;
Bilimoria, Parizad M.;
Yamada, Tomoko;
Bonni, Azad;
Lima, Christopher D.

Publication type:

Article

Avid interactions underlie the Lys63-linked polyubiquitin binding specificities observed for UBA domains.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 8, p. 883, doi. 10.1038/nsmb.1637

By:

Sims, Joshua J.;
Haririnia, Aydin;
Dickinson, Bryan C.;
Fushman, David;
Cohen, Robert E.

Publication type:

Article

Research highlights.

Published in:

2009

By:

Chen, Inês;
Finkelstein, Joshua M.;
Hodges, Maria;
Konforti, Boyana

Publication type:

Abstract

Bacterial ubiquitin-like modifier Pup is deamidated and conjugated to substrates by distinct but homologous enzymes.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 6, p. 647, doi. 10.1038/nsmb.1597

By:

Striebel, Frank;
Imkamp, Frank;
Sutter, Markus;
Steiner, Martina;
Mamedov, Azad;
Weber-Ban, Eilika

Publication type:

Article

E2 interaction and dimerization in the crystal structure of TRAF6.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 6, p. 658, doi. 10.1038/nsmb.1605

By:

Yin, Qian;
Lin, Su-Chang;
Lamothe, Betty;
Lu, Miao;
Lo, Yu-Chih;
Hura, Gregory;
Zheng, Lixin;
Rich, Rebecca L.;
Campos, Alejandro D.;
Myszka, David G.;
Lenardo, Michael J.;
Darnay, Bryant G.;
Wu, Hao

Publication type:

Article