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Title

Production of teicoplanin by a mutant of Actinoplanes teicomyceticus.

Authors

Jae-Chan Lee; Hae-Ryong Park; Dong-Jin Park; Kwang Hee Son; Ki-Hong Yoon; Young-Bae Kim; Chang-Jin Kim

Abstract

Teicoplanin, a glucopeptide antibiotic, was produced by a mutant of Actinoplanes teicomyceticus at 300 mg l-1 using mannose and yeast extract as carbon and nitrogen sources in flask culture and at 500 mg l-1 in 5-l jar fermenter. Teicoplanin production was 25-fold higher than in the parent strain.

Subjects

ANTIBIOTICS; LEAVENING agents; YEAST; CARBON; NITROGEN; MANNOSE

Publication

Biotechnology Letters, 2003, Vol 25, Issue 7, p537

ISSN

0141-5492

Publication type

Academic Journal

DOI

10.1023/A:1022842203917

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