Title: Characteristics of Ischemic Stroke Despite Oral Anticoagulant Use For Atrial Fibrillation.
Authors: Dubé, Marie-Christine; Ducroux, Célina; Daneault, Nicole; Deschaintre, Yan; Jacquin, Grégory; Odier, Céline; Stapf, Christian; Poppe, Alexandre Y.; Romanelli, Giovanni; Gioia, Laura C.
Abstract: Oral anticoagulation (OAC) prevents stroke in atrial fibrillation, yet a residual stroke risk remains. In this single-center retrospective analysis of acute ischemic stroke patients despite OAC, suboptimal OAC treatment is common (30%: inappropriate dosing (17%); patient non-adherence (13%)). Other causes of stroke included OAC interruption (14.5%), a competing stroke mechanism (11.0%), and undetermined breakthrough stroke in 44.5%. Overall, easily modifiable causes of ischemic stroke despite OAC are common. Accordingly, strategies to improve treatment compliance, including appropriate dosing along with guideline-based risk factor and periprocedural OAC management, should be emphasized to improve secondary stroke prevention in this patient population.
Subjects: STROKE patients; ISCHEMIC stroke; PATIENT compliance; ATRIAL fibrillation; ORAL medication
Publication: Canadian Journal of Neurological Sciences, 2024, Vol 51, Issue 6, p851
ISSN: 0317-1671
Publication type: Academic Journal
DOI: 10.1017/cjn.2024.3

Characteristics of Ischemic Stroke Despite Oral Anticoagulant Use For Atrial Fibrillation.

Dubé, Marie-Christine; Ducroux, Célina; Daneault, Nicole; Deschaintre, Yan; Jacquin, Grégory; Odier, Céline; Stapf, Christian; Poppe, Alexandre Y.; Romanelli, Giovanni; Gioia, Laura C.