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Title

Paraneoplastic Anti-Neuronal Nuclear Antibody Type 3 Neurologic Autoimmunity.

Authors

Chandna, Nicholas; Budhram, Adrian; Blanchette, Phillip S; Climans, Seth A

Abstract

The article in the Canadian Journal of Neurological Sciences discusses a case of paraneoplastic anti-neuronal nuclear antibody type 3 neurologic autoimmunity in a patient with small-cell lung cancer. The patient presented with gait difficulty, paraparesis, and sensory neuropathy, leading to a diagnosis of SCLC. The article highlights the importance of neural antibody testing for suspected central nervous system autoimmunity and discusses the diverse manifestations of ANNA-3/DACH1 neurologic autoimmunity. Treatment for PNS involves managing the underlying malignancy and immunosuppressive therapies, with caution advised when considering immune checkpoint inhibitor therapy in rare cases.

Subjects

STIFF-person syndrome; MEDICAL research; NERVE conduction studies; IDIOPATHIC pulmonary fibrosis; POSITRON emission tomography

Publication

Canadian Journal of Neurological Sciences, 2024, Vol 51, Issue 6, p874

ISSN

0317-1671

Publication type

Academic Journal

DOI

10.1017/cjn.2023.324