Title: Chronic Herpes Simplex Virus Encephalitis with Unexpected Neuropathological Findings.
Authors: Sjonnesen, Kirsten; Hader, Walter; Xu, Qi; Jacobs, Julia; Federico, Paolo; Langdon, Kristopher D.; Appendino, Juan P.
Abstract: The article in the Canadian Journal of Neurological Sciences discusses two cases of young patients who underwent epilepsy surgery following chronic Herpes Simplex Virus Encephalitis (HSVE) and exhibited unexpected neuropathological findings of phosphorylated tau accumulation. The patients had contrasting post-operative courses, but both showed chronic inflammation and HSV-1 DNA detectable by PCR. The study highlights the association between HSVE and abnormal phosphorylated tau accumulation, suggesting further investigation into potential long-term neurologic sequelae among HSVE survivors and the consideration of prophylactic acyclovir use during neurosurgical interventions for patients with a history of HSVE.
Subjects: HUMAN herpesvirus 1; VIRAL encephalitis; HERPES simplex virus; ENCEPHALITIS viruses; EPILEPSY surgery
Publication: Canadian Journal of Neurological Sciences, 2024, Vol 51, Issue 6, p880
ISSN: 0317-1671
Publication type: Academic Journal
DOI: 10.1017/cjn.2023.311

Chronic Herpes Simplex Virus Encephalitis with Unexpected Neuropathological Findings.

Sjonnesen, Kirsten; Hader, Walter; Xu, Qi; Jacobs, Julia; Federico, Paolo; Langdon, Kristopher D.; Appendino, Juan P.