Dosimetric comparison of 6 MV and 10 MV flattening filter-free beams using small diameter cone for trigeminal neuralgia radiosurgery.

Apaza Blanco, Oscar Abel; Venencia, Carlos Daniel; Díaz Moreno, Rogelio Manuel; Muñoz, Fabian; Barolo, Franco; Muriano, Oscar

Purpose: To compare the dosimetric characteristics and treatment delivery efficiency of trigeminal neuralgia (TN) stereotactic radiosurgery (SRS) patients previously treated with a 6 MV-FFF (flattening filter-free; radiation beam obtained by removing the flattening filter) beam versus those re-planned with a 10 MV-FFF beam using a conical collimator on the TrueBeam Novalis STx linear accelerator. Methods: Eleven patients with TN previously treated with a 6 MV-FFF beam following the SRS protocol of 90 Gy in a single fraction were selected. Plans were recalculated using 10 MV-FFF beam, maintaining the same dose prescription and beam angle configuration used with 6 MV-FFF beam. The dose gradient, volumes receiving 20 and 10 Gy, maximum dose and dose to 10% of the brainstem were recorded for both the energies. Efficiency was assessed by the average monitor unit (MU) and time per arc. The 10 MV-FFF machine was configured in the treatment planning system (TPS) to measure the tissue phantom ratio (TPR), dose profiles and scatter factors using RAZOR, PTW-60012 diodes and EBT3 radiochromic films. Results: Compared to the 6 MV-FFF, the 10 MV-FFF plans exhibit average increments in dose gradient, volume of 20 Gy and volume of 10 Gy of 3.8, 17.1 and 17.8%, respectively. Average increases of 6.5 and 18.1% were obtained for maximum dose and dose to 10% of the brainstem, respectively. An average increase of 31 MU/arc was observed for the 10 MV-FFF plans, with a 40% reduction in treatment time per arc. The TPR for the 10 MV-FFF beams increased by 10%, and a penumbra width of 0.3 mm was observed. Scatter factor increments of 15, 13.5, 12.7 and 10.3% were observed for the 6 MV-FFF over the 10 MV-FFF for cones of 4, 5, 6 and 7 mm, respectively. Conclusions: In TN SRS, the utilisation of 10 MV-FFF beams reduces treatment duration but results in an increased brainstem radiation dose. To mitigate this increase in brainstem dose, it is necessary to adjust the isocentre position.

PHARMACEUTICAL arithmetic; TRIGEMINAL neuralgia; DOSIMETERS; RADIOSURGERY; RADIATION dosimetry; TREATMENT effectiveness; DESCRIPTIVE statistics; COMPUTER-assisted surgery; BRAIN stem; COMPARATIVE studies; RADIATION doses; EVALUATION

Journal of Radiotherapy in Practice, 2025, Vol 23, Issue 4, p1

1460-3969

Academic Journal

10.1017/S1460396924000256