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- Title
A dose-response meta-analysis reveals an association between vitamin B12 and colorectal cancer risk.
- Authors
Nai-Hui Sun; Xuan-Zhang Huang; Shuai-Bo Wang; Yuan Li; Long-Yi Wang; Hong-Chi Wang; Chang-Wang Zhang; Cong Zhang; Hong-Peng Liu; Zhen-Ning Wang; Sun, Nai-Hui; Huang, Xuan-Zhang; Wang, Shuai-Bo; Li, Yuan; Wang, Long-Yi; Wang, Hong-Chi; Zhang, Chang-Wang; Zhang, Cong; Liu, Hong-Peng; Wang, Zhen-Ning
- Abstract
<bold>Objective: </bold>The current meta-analysis evaluated the association between vitamin B12 intake and blood vitamin B12 level and colorectal cancer (CRC) risk.<bold>Design: </bold>The PubMed and EMBASE databases were searched. A dose-response analysis was performed with generalized least squares regression, with the relative risk (RR) and 95 % CI as effect values.<bold>Setting: </bold>The meta-analysis included seventeen studies.<bold>Subjects: </bold>A total of 10 601 patients.<bold>Results: </bold>The non-linear dose-response relationship between total vitamin B12 intake and CRC risk was insignificant (P=0·690), but the relationship between dietary vitamin B12 intake and CRC risk was significant (P<0·001). Every 4·5 μg/d increment in total and dietary vitamin B12 intake was inversely associated with CRC risk (total intake: RR=0·963; 95 % CI 0·928, 0·999; dietary intake: RR=0·914; 95 % CI 0·856, 0·977). The inverse association between vitamin B12 intake and CRC risk was also significant when vitamin B12 intake was over a dosage threshold, enhancing the non-linear relationship. The non-linear dose-response relationship between blood vitamin B12 level and CRC risk was insignificant (P=0·219). There was an insignificant association between every 150 pmol/l increment in blood vitamin B12 level and CRC risk (RR=1·023; 95 % CI 0·881, 1·187).<bold>Conclusions: </bold>Our meta-analysis indicates that evidence supports the use of vitamin B12 for cancer prevention, especially among populations with high-dose vitamin B12 intake, and that the association between CRC risk and total vitamin B12 intake is stronger than between CRC risk and dietary vitamin B12 intake only.
- Subjects
COLON cancer risk factors; VITAMIN B in human nutrition; DOSE-response relationship in biochemistry; BLOOD testing; EVIDENCE-based medicine; COLON tumors; COMPARATIVE studies; DIET; RESEARCH methodology; MEDICAL cooperation; META-analysis; RECTUM tumors; RESEARCH; VITAMIN B12; EVALUATION research
- Publication
Public Health Nutrition, 2016, Vol 19, Issue 8, p1446
- ISSN
1368-9800
- Publication type
Academic Journal
- DOI
10.1017/S136898001500261X