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Title

Personalized high-definition transcranial direct current stimulation improves cognition following carbon monoxide poisoning induced amnesia: A case report.

Authors

Schneider, Brett S; McInnis, Melvin; Di Rita, Victor; Hampstead, Benjamin M

Abstract

Objective: High-definition transcranial direct current stimulation (HD-tDCS) has the potential to improve cognitive functioning following neurological injury and in neurodegenerative conditions. In this case report, we present the first use of HD-tDCS in a person with severe anterograde amnesia following carbon monoxide poisoning. Method: The participant underwent two rounds of HD-tDCS that were separated by 3 months (Round 1 = 30 sessions; Round 2 = 31 sessions). We used finite element modeling of the participant's structural MRI to develop an individualized montage that targeted multiple brain regions involved in memory encoding, as identified by Neurosynth. Results: Overall, the participant's objective cognitive functioning improved significantly following Round 1, declined during the 2 months without HD-tDCS, and again improved following Round 2. Subjective informant reports from family and medical personnel followed this same pattern of improvement following each round with a decline in between rounds. We also provide preliminary evidence of altered brain activity during a learning/memory task using functional near-infrared spectroscopy, which may help establish the physiological effects of HD-tDCS in future work. Conclusion: Overall, these findings reinforce the potential value of HD-tDCS as a user-friendly method of enhancing cognition following anoxic/hypoxic brain injury.

Subjects

TRANSCRANIAL direct current stimulation; CARBON monoxide poisoning; MEDICAL personnel; ELECTRIC stimulation; BRAIN stimulation

Publication

Journal of the International Neuropsychological Society, 2024, Vol 30, Issue 10, p1015

ISSN

1355-6177

Publication type

Academic Journal

DOI

10.1017/S1355617724000304

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