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Title

Poster 82 Intronic Single Nucleotide Polymorphism of the CALM‐1 Gene Is Significantly Associated With Knee Osteoarthritis: A Case Control Study.

Authors

Sanghi, Divya; Avasthi, Sachin; Ganesh, S.; Srivastava, Rajeshwar N.

Abstract

The Japanese population has shown a higher incidence of osteoarthritis in patients with intronic and core promoter single nucleotide polymorphism (SNP) in the CALM-1 gene. Among SNP positive cases and controls, 5 cases (8.7%) and no controls were heterozygosis for the occurrence of SNP. Genetic polymorphism in relation to the intronic region of the Calm-1 gene was studied by DNA extraction, polymerase chain reaction and restriction fragment length polymorphism method.

Subjects

SINGLE nucleotide polymorphisms; KNEE osteoarthritis; GENETIC polymorphisms; OSTEOARTHRITIS; KNEE pain; RESTRICTION fragment length polymorphisms

Publication

PM & R: Journal of Injury, Function & Rehabilitation, 2011, Vol 3, pS168

ISSN

1934-1482

Publication type

Academic Journal

DOI

10.1016/j.pmrj.2011.08.036

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