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A Novel Transgenic Rat Model with a Full Alzheimer's-Like Amyloid Pathology Displays Pre-Plaque Intracellular Amyloid-β-Associated Cognitive Impairment.
- Published in:
- Journal of Alzheimer's Disease, 2010, v. 20, n. 1, p. 113, doi. 10.3233/JAD-2010-1349
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- Publication type:
- Article
Rat transgenic models with a phenotype of intracellular Abeta accumulation in hippocampus and cortex.
- Published in:
- 2004
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- Publication type:
- journal article
Research and Practice in Alzheimer's Disease, by B. Vellas, L.J. Fitten, B. Winblad, H. Feldman, M. Grundman, E. Giacobini and A. Kurz, eds.
- Published in:
- 2003
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- Publication type:
- Book Review
Nerve Growth Factor Compromise in Down Syndrome.
- Published in:
- Frontiers in Aging Neuroscience, 2021, v. 13, p. 1, doi. 10.3389/fnagi.2021.719507
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- Publication type:
- Article
Similarities in the ultrastructural distribution of nerve growth factor receptor-like immunoreactivity in cerebellar Purkinje cells of the neonatal and colchicine-treated adult rat.
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- Journal of Comparative Neurology, 1991, v. 305, n. 2, p. 189, doi. 10.1002/cne.903050203
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- Publication type:
- Article
Choline acetyltransferase-immunoreactive profiles are presynaptic to primary sensory fibers in the rat superficial dorsal horn.
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- Journal of Comparative Neurology, 1990, v. 295, n. 3, p. 370, doi. 10.1002/cne.902950303
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- Publication type:
- Article
Ultrastructural and neurochemical analysis of synaptic input to trigemino-thalamic projection neurones in lamina I of the rat: A combined immunocytochemical and retrograde labelling study.
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- Journal of Comparative Neurology, 1989, v. 285, n. 4, p. 467, doi. 10.1002/cne.902850405
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- Publication type:
- Article
Reimagining cholinergic therapy for Alzheimer's disease.
- Published in:
- 2022
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- Publication type:
- journal article
Evolution of neuroinflammation across the lifespan of individuals with Down syndrome.
- Published in:
- 2020
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- Publication type:
- journal article
The cholinergic system in the pathophysiology and treatment of Alzheimer's disease.
- Published in:
- 2018
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- Publication type:
- journal article
Long-Lasting Rescue of Age-Associated Deficits in Cognition and the CNS Cholinergic Phenotype by a Partial Agonist Peptidomimetic Ligand of TrkA.
- Published in:
- Journal of Neuroscience, 2004, v. 24, n. 37, p. 8009, doi. 10.1523/JNEUROSCI.1508-04.2004
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- Publication type:
- Article
IC‐P‐054: AMYLOID AND MICROGLIAL ACTIVATION SYNERGY LEADS TO HYPOMETABOLISM IN THE AD BRAIN: MICROPET LONGITUDINAL STUDY.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 14, p. P51, doi. 10.1016/j.jalz.2018.06.2119
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- Publication type:
- Article
Changes of basal forebrain volume along the Alzheimer's disease continuum in Down syndrome.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.067239
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- Publication type:
- Article
ELUCIDATING THE COMBINED EFFECTS OF AMYLOID AND TAU IN A NOVEL BIGENIC RAT MODEL WITH HUMAN ALZHEIMER'S DISEASE‐LIKE PATHOLOGY.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.061902
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- Publication type:
- Article
An M1/sigma‐1 receptor agonist prevents cognitive deficits, reduces amyloid plaques and neuroinflammation in a transgenic rat model of Alzheimer's amyloid pathology.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 10, p. 1, doi. 10.1002/alz.069100
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- Publication type:
- Article
Nerve growth factor (NGF) pathway biomarkers in Down syndrome prior to and after the onset of clinical Alzheimer's disease: A paired CSF and plasma study.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 4, p. 605, doi. 10.1002/alz.12229
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- Publication type:
- Article
Combined treatment with the microdose lithium formulation NP03 and S‐adenosylmethionine reduces cognitive decline and Alzheimer's‐like amyloid pathology in Mcgill‐R‐Thy1‐APP rats: Nonhuman/Target identification and validation studies: Other
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.043443
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- Publication type:
- Article
Investigating the role of neuronal oxidative stress in early Alzheimer's disease pathology: Molecular and cell biology/oxidative stress.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.041171
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- Publication type:
- Article
P2‐199: HIPPOCAMPAL LEVEL OF LSD1 CORRELATES WITH INTRACELLULAR AMYLOID‐BETA LOAD, INFLAMMATION, NEURODEGENERATION AND COGNITIVE DECLINE IN AN AD‐LIKE RAT MODEL.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P652, doi. 10.1016/j.jalz.2019.06.2606
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- Publication type:
- Article
P3‐338: AMYLOID AND MICROGLIAL ACTIVATION SYNERGY LEADS TO HYPOMETABOLISM IN AD BRAIN: MICROPET LONGITUDINAL STUDY.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P1211, doi. 10.1016/j.jalz.2018.06.1699
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- Publication type:
- Article
P3‐153: VALIDATING LXRS/ABCA1/APOE AXIS INTERVENTION AS A POTENTIAL THERAPEUTIC TAGET TO PREVENT AMYLOID BETA CLEARANCE IMBALANCE.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P1126, doi. 10.1016/j.jalz.2018.06.1511
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- Publication type:
- Article
P3‐094: A NOVEL TRANSGENIC RAT MODEL OF TAUOPATHY WITH SEVERE BRAIN ATROPHY, GLIOSIS AND COGNITIVE DEFICITS.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P1101, doi. 10.1016/j.jalz.2018.06.1450
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- Publication type:
- Article
P3‐093: VIRAL VECTOR‐MEDIATED OVEREXPRESSION OF HUMAN TAU IN THE RAT LOCUS COERULEUS: TAU LONG‐TERM EXPRESSION AND PATHOLOGICAL CHANGES.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P1101, doi. 10.1016/j.jalz.2018.06.1449
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- Publication type:
- Article
P2‐189: CHRONOLOGICAL CORRELATION BETWEEN LSD1, β‐AMYLOID AND PRO‐INFLAMMATORY MARKERS WITH COGNITIVE PERFORMANCE IN AN AD‐LIKE TRANSGENIC RAT MODEL.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P741, doi. 10.1016/j.jalz.2018.06.876
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- Publication type:
- Article
P2‐187: BUILDUP OF INTRACELLULAR Aβ ELICITS NEURONAL INFLAMMATION, INDEPENDENT OF PLAQUE PATHOLOGY.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P740, doi. 10.1016/j.jalz.2018.06.874
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- Publication type:
- Article
IC‐P‐054: AMYLOID AND MICROGLIAL ACTIVATION SYNERGY LEADS TO HYPOMETABOLISM IN THE AD BRAIN: MICROPET LONGITUDINAL STUDY.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P51, doi. 10.1016/j.jalz.2018.06.2119
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- Publication type:
- Article
AF710B, an M1/sigma‐1 receptor agonist with long‐lasting disease‐modifying properties in a transgenic rat model of Alzheimer's disease.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, n. 6, p. 811, doi. 10.1016/j.jalz.2017.11.009
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- Publication type:
- Article
Substance P Immunoreaction and Acetylcholinesterase Activity in the Cornea and Gasserian Ganglion.
- Published in:
- Ophthalmic Research, 1983, v. 15, n. 6, p. 280, doi. 10.1159/000265273
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- Publication type:
- Article
NGF AND BDNF DYSMETABOLISM IN A TRANSGENIC RAT MODEL OF ALZHEIMER’S DISEASE.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P322, doi. 10.1016/j.jalz.2017.06.029
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- Publication type:
- Article
AMYLOID β-DRIVEN DNA DEMETHYLATION AS A TARGET FOR ALZHEIMER’S DISEASE.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P1269, doi. 10.1016/j.jalz.2017.06.1899
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- Publication type:
- Article
PRECLINICAL ASSESSMENT OF KAL-ABP TARGET ENGAGEMENT AND EFFICACY USING PET, MRI AND CSF BIOMARKERS.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P591, doi. 10.1016/j.jalz.2017.07.224
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- Publication type:
- Article
COMBINED GLOBAL AND REGIONAL AMYLOID EFFECT ON THE DEFAULT MODE NETWORK LEADS TO COGNITIVE DECLINE.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P459, doi. 10.1016/j.jalz.2017.06.468
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- Publication type:
- Article
ELEVATED CSF LEVELS OF NEUROFILAMENT LIGHT CHAIN IS ASSOCIATED WITH GRAY MATTER NEURODEGENERATION IN BOTH HUMANS AND TRANSGENIC RAT MODEL OF ALZHEIMER’S DISEASE.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P1130, doi. 10.1016/j.jalz.2017.06.1642
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- Publication type:
- Article
IDENTIFYING THE NEURONAL Aβ-IMMUNOPOSITIVE POOL WITHIN THE HUMAN HIPPOCAMPUS.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P231, doi. 10.1016/j.jalz.2017.06.068
- By:
- Publication type:
- Article
ELEVATED CSF LEVELS OF NEUROFILAMENT LIGHT CHAIN IS ASSOCIATED WITH GRAY MATTER NEURODEGENERATION IN BOTH HUMANS AND TRANSGENIC RAT MODEL OF ALZHEIMER’S DISEASE.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P41, doi. 10.1016/j.jalz.2017.06.2320
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- Publication type:
- Article
IDENTIFYING THE NEURONAL Aβ-IMMUNOPOSITIVE POOL WITHIN THE HUMAN HIPPOCAMPUS.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P313, doi. 10.1016/j.jalz.2017.06.253
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- Publication type:
- Article
AMYLOID-BETA MODULATES CEREBRAL METABOLIC NETWORK IN RATS AND HUMANS.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P38, doi. 10.1016/j.jalz.2017.06.2317
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- Publication type:
- Article
AMYLOID-BETA MODULATES CEREBRAL METABOLIC NETWORK IN RATS AND HUMANS.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P557, doi. 10.1016/j.jalz.2017.07.163
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- Publication type:
- Article
INTRANASAL INTERVENTION OF THE LXRS-APOE-MICROGLIA AXIS TO IMPROVE BRAIN BETA-AMYLOID CLEARANCE IN A TRANSGENIC MOUSE MODEL OF AD.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P995, doi. 10.1016/j.jalz.2017.06.1371
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- Publication type:
- Article
EARLY AND LATE NEUROINFLAMMATORY EVENTS AS ALZHEIMER’S DISEASE PATHOLOGY EVOLVES IN DOWN SYNDROME INDIVIDUALS.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P984, doi. 10.1016/j.jalz.2017.06.1340
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- Publication type:
- Article
IMPAIRED REVERSAL OF HIPPOCAMPAL LONG-TERM POTENTIATION IN APP-OVEREXPRESSING RATS IN VIVO.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P283, doi. 10.1016/j.jalz.2017.06.178
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- Publication type:
- Article
REST HIPPOCAMPAL AND CORTICAL LEVELS CORRELATE WITH COGNITIVE PERFORMANCE IN A RAT MODEL OF EARLY ALZHEIMER'S DISEASE.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P319, doi. 10.1016/j.jalz.2017.06.021
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- Publication type:
- Article
An inflammatory and trophic disconnect biomarker profile revealed in Down syndrome plasma: Relation to cognitive decline and longitudinal evaluation.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, n. 11, p. 1132, doi. 10.1016/j.jalz.2016.05.001
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- Publication type:
- Article
DNA DEMETHYLATION AND REMETHYLATION IN ALZHEIMER’S PATHOLOGY.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P223, doi. 10.1016/j.jalz.2016.06.399
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- Publication type:
- Article
AMYLOID-BETA 1-42 (Aβ1-42) LEVELS IN THE CEREBROSPINAL FLUID ASSOCIATE WITH SPATIAL MEMORY PERFORMANCE IN AGED BUT NOT IN ADULT MCGILL-R-THY1-APP RATS.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P440, doi. 10.1016/j.jalz.2016.06.849
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- Publication type:
- Article
AMYLOID-INDUCED MICROGLIAL ACTIVITY IN THALAMOCORTICAL CIRCUITS PREDICTS SUBSEQUENT COGNITIVE DECLINE.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P627, doi. 10.1016/j.jalz.2016.06.1258
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- Publication type:
- Article
SYNERGISM BETWEEN BASELINE AMYLOIDOSIS AND NEURONAL INJURY AS DETERMINANTS OF LEARNING DEFICITS IN AD TRANSGENIC RAT MODEL.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P77, doi. 10.1016/j.jalz.2016.06.131
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- Publication type:
- Article
SYNERGISM BETWEEN BRAIN AMYLOID ACCUMULATION AND NEURONAL INJURY IN CORTICAL-SUBCORTICAL CIRCUITS CAUSES MEMORY DECLINES IN ANIMAL MODELS.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P504, doi. 10.1016/j.jalz.2016.06.1000
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- Publication type:
- Article
NP03 INHIBITS BACE1 AND GSK-3B FOR THE PREVENTION OF EARLY ALZHEIMER’S-LIKE AMYLOID NEUROPATHOLOGY IN TRANSGENIC RATS.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P834, doi. 10.1016/j.jalz.2016.06.1704
- By:
- Publication type:
- Article
AMYLOID-INDUCED MICROGLIAL ACTIVITY IN THALAMOCORTICAL CIRCUITS PREDICTS SUBSEQUENT COGNITIVE DECLINE.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P28, doi. 10.1016/j.jalz.2016.06.037
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- Publication type:
- Article