Results
Title

Effect of intravenous tranexamic acid administration on blood loss during and after cesarean delivery

Authors

Movafegh, Ali; Eslamian, Laleh; Dorabadi, Azita

Abstract

Objective: To assess the effect of intravenous tranexamic acid on blood loss during and after cesarean delivery.Methods: One hundred pregnant women were randomized to receive either 10 mg/kg of tranexamic acid or placebo intravenously 20 minutes before incision in a double-blind controlled study. Postplacental delivery blood loss, postoperative hemorrhage 2 hours after surgery, and oxytocin administration were recorded.Results: The patients' mean age, weight, and duration of surgery were similar between the 2 groups. Mean blood loss was significantly less in the tranexamic acid group compared with the control group for both intraoperative bleeding (262.5 ± 39.6 vs 404.7 ± 94.4 mL) and postoperative bleeding (67.1 ± 6.5 vs 141.0 ± 33.9 mL; PConclusion: Intravenous tranexamic acid decreased intra- and postoperative blood loss and oxytocin administered in patients delivered by cesarean.

Subjects

CESAREAN section; CARBOCYCLIC acids; DRUG administration; BLOOD loss estimation; DELIVERY (Obstetrics); PLACEBOS; OXYTOCIN; HEMORRHAGE prevention; ANTIFIBRINOLYTIC agents; SURGICAL blood loss; TRANEXAMIC acid; COMPARATIVE studies; HEMORRHAGE; INTRAVENOUS therapy; RESEARCH methodology; MEDICAL cooperation; PUERPERAL disorders; RESEARCH; EVALUATION research; UTERINE hemorrhage; RANDOMIZED controlled trials; BLIND experiment; OXYTOCICS; PREVENTION; THERAPEUTICS

Publication

International Journal of Gynecology & Obstetrics, 2011, Vol 115, Issue 3, p224

ISSN

0020-7292

Publication type

Academic Journal

DOI

10.1016/j.ijgo.2011.07.015