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- Title
dXNP, a Drosophila homolog of XNP/ATRX, induces apoptosis via Jun-N-terminal kinase activation
- Authors
Lee, Nam Gon; Hong, Yoon Ki; Yu, Si Young; Han, Seung Yeop; Geum, Dongho; Cho, Kyoung Sang
- Abstract
Abstract: XNP/ATRX, a causative gene of X-linked α-thalassemia/mental retardation syndrome, encodes an SNF2 family ATPase/helicase protein. To better understand the role of XNP/ATRX in development, we isolated and characterized a Drosophila XNP/ATRX homolog, dXNP, which contains highly conserved SNF2 and helicase domains. Ectopically expressed dXNP induced strong apoptosis in the developing eye and wing, but did not affect cell cycle progression or the expression of wingless and engrailed, essential regulators of development. The dXNP-induced apoptosis was strongly suppressed by DJNKK/hemipterous mutation, and dXNP increased JNK activity. Taken together, these results suggest that dXNP regulates apoptosis via JNK activation.
- Subjects
DROSOPHILA; INTELLECTUAL disabilities; CELL death; APOPTOSIS
- Publication
FEBS Letters, 2007, Vol 581, Issue 14, p2625
- ISSN
0014-5793
- Publication type
Academic Journal
- DOI
10.1016/j.febslet.2007.05.005