A component of BRAF-HDAC complex, BHC80, is required for neonatal survival in mice

Iwase, Shigeki; Shono, Naomi; Honda, Arata; Nakanishi, Tomoko; Kashiwabara, Shin-ichi; Takahashi, Satoru; Baba, Tadashi

Abstract: BHC80 is a component of BRAF-HDAC complex (BHC) involved in transcriptional repression of neuron-specific genes in non-neuronal cells. However, BHC80 is present in both neuronal and non-neuronal cells. To explore the physiological importance of BHC80 in vivo, and the precise mechanism underlying neuron-specific gene repression by BHC80, we have produced mutant mice lacking Bhc80. The loss of Bhc80 resulted in neonatal lethality without sucking mother’s breast milk sufficiently. Although Bhc80-deficient mice showed no developmental defect in the neuronal and non-neuronal tissues, Bhc80 is indispensable for the survival of neonatal pups.

HEREDITY; BREAST milk; PRESERVATION of organs, tissues, etc.; MICE

FEBS Letters, 2006, Vol 580, Issue 13, p3129

0014-5793

Academic Journal

10.1016/j.febslet.2006.04.065