Results
Title

Prognostic Significance of FDG Uptake of Bone Marrow on PET/CT in Patients With Non-Small-Cell Lung Cancer After Curative Surgical Resection.

Authors

Jeong Won Lee; Ju Ock Na; Du-Young Kang; Seock Yeol Lee; Sang Mi Lee; Lee, Jeong Won; Na, Ju Ock; Kang, Du-Young; Lee, Seock Yeol; Lee, Sang Mi

Abstract

Background: This study evaluated the relationship between 18F-fluorodeoxyglucose (FDG) uptake in bone marrow (BM) on positron emission tomography (PET)/computed tomography (CT) imaging and serum inflammatory markers and assessed the prognostic value of FDG uptake of BM in patients with non-small-cell lung cancer (NSCLC) who underwent curative surgical resection.Patients and Methods: We retrospectively enrolled 110 NSCLC patients who underwent FDG PET/CT imaging and subsequent curative surgical resection. The maximum standardized uptake value of NSCLC (Tmax), mean FDG uptake of BM (BM SUV), and BM to liver uptake ratio (BLR) were measured. The relationships between BM SUV, BLR, and serum inflammatory markers were evaluated and the prognostic significance of PET/CT parameters for predicting recurrence-free survival (RFS) and overall survival (OS) were assessed.Results: BM SUV and BLR were significantly associated with serum C-reactive protein (CRP) level, white blood cell count, and the neutrophil to lymphocyte ratio (NLR). BLR was also significantly correlated with serum albumin and the platelet to lymphocyte ratio. In univariate analysis, tumor, node, metastases (TNM) stage, serum CRP level, NLR, Tmax, and BLR were significant prognostic factors for RFS and OS, whereas histopathology and tumor size were significant prognostic factors for RFS. In multivariate analysis, BLR, histopathology, TNM stage, and Tmax were independent prognostic factors for RFS and TNM stage and Tmax were independent prognostic factors for OS.Conclusion: FDG uptake of BM on PET/CT imaging was correlated with serum inflammatory markers and was an independent predictor for RFS, along with FDG uptake of NSCLC.

Subjects

ADENOCARCINOMA; BONE marrow; BONE marrow cancer; CANCER relapse; DEOXY sugars; LONGITUDINAL method; LUNG cancer; LUNG tumors; METASTASIS; PROGNOSIS; RADIOPHARMACEUTICALS; SQUAMOUS cell carcinoma; SURVIVAL; TUMOR classification; RETROSPECTIVE studies; SURGERY

Publication

Clinical Lung Cancer, 2017, Vol 18, Issue 2, p198

ISSN

1525-7304

Publication type

Academic Journal

DOI

10.1016/j.cllc.2016.07.001