Semicontinuous processes have been studied in recent years for many purposes, including extractive, azeotropic, and reactive distillations, and reactive liquid-liquid extraction. In this paper, using a continuous process as a base case, heuristics are introduced to create semicontinuous process designs. The methodology for synthesizing a semi-continuous separation process (including the process units, connectivity, control system, integration with chemical reaction(s), and choice of transitional modes) is presented based on experiences involving prior case studies.