3D printing and continuous flow chemistry technology to advance pharmaceutical manufacturing in developing countries.

Sagandira, Cloudius R.; Siyawamwaya, Margaret; Watts, Paul

The realization of a downward spiralling of diseases in developing countries requires them to become self-sufficient in pharmaceutical products. One of the ways to meet this need is by boosting the local production of active pharmaceutical ingredients and embracing enabling technologies. Both 3D printing and continuous flow chemistry are being exploited rapidly and they are opening huge avenues of possibilities in the chemical and pharmaceutical industries due to their well-documented benefits. The main barrier to entry for the continuous flow chemistry technique in low-income settings is the cost of set-up and maintenance through purchasing of spare flow reactors. This review article discusses the technical considerations for the convergence of state-of-the-art technologies, 3D printing and continuous flow chemistry for pharmaceutical manufacturing applications in developing countries. An overview of the 3D printing technique and its application in fabrication of continuous flow components and systems is provided. Finally, quality considerations for satisfying regulatory requirements for the approval of 3D printed equipment are underscored. An in-depth understanding of the interrelated aspects in the implementation of these technologies is crucial for the realization of sustainable, good quality chemical reactionware.

FLOW chemistry; THREE-dimensional printing; PHARMACEUTICAL technology; DEVELOPING countries; MANUFACTURED products; TECHNOLOGY convergence

Arabian Journal of Chemistry, 2020, Vol 13, Issue 11, p7886

1878-5352

Academic Journal

10.1016/j.arabjc.2020.09.020