Results
Title

Multi-step continuous flow synthesis of fluconazole.

Authors

Szeto, Judy; Vu, Vi-Anh; Malerich, Jeremiah P.; Collins, Nathan

Abstract

The development of a flow chemistry approach to the anti-fungal fluconazole is described. A continuous, two-reactor, three-step synthesis of fluconazole from 2-chloro-2′,4′-difluoroacetophenone was achieved with no intermediate purification. The synthesis has been successfully demonstrated on a Vapourtec commercial flow chemistry system.ᅟ

Subjects

FLUCONAZOLE; ANTIFUNGAL agent synthesis; FLOW chemistry; ACETOPHENONE synthesis; CHEMICAL processes

Publication

Journal of Flow Chemistry, 2019, Vol 9, Issue 1, p35

ISSN

2062-249X

Publication type

Academic Journal

DOI

10.1007/s41981-018-0019-0