Practical Guidance for the Use of SGLT2 Inhibitors in Heart Failure.

Cavallari, Ilaria; Crispino, Simone Pasquale; Segreti, Andrea; Ussia, Gian Paolo; Grigioni, Francesco

Despite continuous advances in both diagnosis and management, heart failure (HF) still represents a major worldwide health issue. Recently, sodium-glucose co-transporter 2 inhibitors (SGLT2i) have demonstrated to reduce cardiovascular death and hospitalization for HF across the entire spectrum of left ventricular ejection fraction. Therefore, dapagliflozin, empagliflozin and sotagliflozin are now recommended as part of the foundational therapy of HF. These agents are characterized by limited contraindications, low cost, non-relevant adverse effects and no need for titration. Although they have a prominent role in the latest recommendations for HF, drug prescriptions are definitely lower than the number of potentially eligible patients. In fact, awareness gaps, therapeutic inertia, concerns about safety and simultaneous initiation of comprehensive medical therapy may represent barriers to their use. This article aims to offer an overview of current knowledge on SGLT2i in HF and provide a comprehensive and updated practical guide on their use in de novo and chronic HF, including potential scenarios that a clinician, cardiologist or others, may face in everyday clinical practice.

PREVENTION of drug side effects; PROFESSIONAL practice; DIURETICS; ANTIHYPERTENSIVE agents; CARDIOVASCULAR diseases risk factors; PROFESSIONS; VENTRICULAR ejection fraction; CARDIOLOGISTS; EMPAGLIFLOZIN; MEDICAL protocols; DAPAGLIFLOZIN; HOSPITAL care; SODIUM-glucose cotransporter 2 inhibitors; PHYSICIANS; NATRIURETIC peptides; HEART failure; DIFFUSION of innovations; PATIENT safety

American Journal of Cardiovascular Drugs, 2023, Vol 23, Issue 6, p609

1175-3277

Academic Journal

10.1007/s40256-023-00601-9