Risk factors of bloodstream infections in recipients after liver transplantation: a meta-analysis.

He, Qiang; Liu, Pin; Li, Xuan; Su, Kewen; Peng, Dan; Zhang, Zhongshuang; Xu, Wei; Qin, Zhen; Chen, Shuai; Li, Yingli; Qiu, Jingfu

Purpose: Bloodstream infection (BSI) is an important cause of adverse outcomes for recipients with liver transplantation (LT). This meta-analysis aimed to identify risk factors associated with post-LT BSI.Methods: Relevant studies published up to June 2017 were searched from seven electronic databases. The studies were reviewed according to the inclusion and exclusion criteria. The Z test was used to determine the pooled odds ratio (OR) or standardized mean difference (SMD) of the risk factors. ORs and their corresponding 95% confidence intervals (CIs), or SMDs and their corresponding 95% CIs were used to identify the significant difference of risk factors.Results: Seventeen studies enrolling 4410 recipients were included. Eleven risk factors were identified to be associated with BSI after LT: male recipient (OR = 1.28), ascites (OR = 1.68), model for end-stage liver disease (MELD) score (SMD = 0.20), Child-Pugh class C (OR = 1.69), operation time (SMD = 0.18), incompatible blood type (OR = 2.87), operative blood loss (SMD = 0.33), rejection (OR = 1.72), biliary complications (OR = 1.91), hemodialysis (OR = 3.37), and retransplantation (OR = 2.86).Conclusions: Although some risk factors were identified as significant factors for BSI after LT, which may provide a basis for clinical prevention, well-designed prospective studies should be done to overcome the limitations of this study.

BACTERIAL disease risk factors; ASCITES; BIOLOGICAL models; CONFIDENCE intervals; HEMODIALYSIS; LIVER failure; LIVER transplantation; META-analysis; SURGICAL complications; TRANSPLANTATION of organs, tissues, etc.; SYSTEMATIC reviews; DISEASE relapse; TREATMENT duration; ODDS ratio

Infection, 2019, Vol 47, Issue 1, p77

0300-8126

Academic Journal

10.1007/s15010-018-1230-5