Anti-inflammatory alkaloids from the cold-seep-derived fungus Talaromyces helicus SCSIO41311.

Cong, Mengjing; Zhang, Yi; Feng, Xinyue; Pang, Xiaoyan; Liu, Yonghong; Zhang, Xiaoyong; Yang, Zhiyou; Wang, Junfeng

One new natural alkaloid, chaetominine B (1), together with twenty known compounds was isolated from the South China Sea cold-seep-derived fungus Talaromyces helicus SCSIO41311. Their structures were elucidated on the basis of nuclear magnetic resonance spectrum (NMR), mass spectrometry (MS) and ECD calculation, as well as comparing with previous literatures. Among them, twelve compounds showed potent NO inhibitory activities and two of them, azaspirofurans A (13) and fumiquinones B (21), exhibited NO inhibitory effects more than the positive control eicosapentaenoic acid (EPA) with IC50 values of 9.65 and 15.54 μM, respectively. Moreover, compound 13 attenuated LPS-induced imbalance of cytokines release such as TNF-α, IL-1β, IL-4, and IL-10. Additionally, the NMR data and absolute configuration of compound 20 were first reported.

TALAROMYCES; ALKALOIDS; EICOSAPENTAENOIC acid; NUCLEAR magnetic resonance; FUNGI; MASS spectrometry

3 Biotech, 2022, Vol 12, Issue 8, p1

2190-572X

Academic Journal

10.1007/s13205-022-03237-9