Results
Title

Pleiotropic role of PARP1: an overview.

Authors

Kumar, Vikas; Kumar, Anurag; Mir, Khursheed Ul Islam; Yadav, Vandana; Chauhan, Shyam Singh

Abstract

Poly (ADP-ribose) polymerase 1 (PARP1) protein is encoded by the PARP1 gene located on chromosome 1 (1q42.12) in human cells. It plays a crucial role in post-translational modification by adding poly (ADP-ribose) (PAR) groups to various proteins and PARP1 itself by utilizing nicotinamide adenine dinucleotide (NAD ) as a substrate. Since the discovery of PARP1, its role in DNA repair and cell death has been its identity. This is evident from an overwhelmingly high number of scientific reports in this regard. However, PARP1 also plays critical roles in inflammation, metabolism, tumor development and progression, chromatin modification and transcription, mRNA stability, and alternative splicing. In the present study, we attempted to compile all the scattered scientific information about this molecule, including the structure and multifunctional role of PARP1 in cancer and non-cancer diseases, along with PARP1 inhibitors (PARPis). Furthermore, for the first time, we have classified PARP1-mediated cell death for ease of understanding its role in cell death pathways.

Subjects

POLY ADP ribose; ADP-ribosylation; POST-translational modification; DNA repair; TECHNICAL reports; CELL death; CANCER invasiveness; CHROMOSOMES

Publication

3 Biotech, 2022, Vol 12, Issue 1, p1

ISSN

2190-572X

Publication type

Academic Journal

DOI

10.1007/s13205-021-03038-6