Works matching DE "UBIQUITIN ligases"

Results: 3436

Linear Ubiquitination of Hemocyanin Mediated by LUBEL Regulates Innate Immunity in Penaeus vannamei.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 11, p. 5110, doi. 10.3390/ijms26115110

By:

Zhang, Xiaojun;
Zhang, Hanfeng;
Zhang, Yueling;
Lin, Zhongyang

Publication type:

Article

The tumor suppressor FAT1 controls YAP/TAZ protein degradation and tumor cell proliferation through E3 ligase MIB2.

Published in:

PLoS ONE, 2025, v. 20, n. 6, p. 1, doi. 10.1371/journal.pone.0325535

By:

Li, Rui;
Strilic, Boris;
Jin, Young-June;
Shao, Jingchen;
Peng, Yundong;
Wang, Lei;
Quan, Qi;
Wang, Zhiyong;
Graumann, Johannes;
Gutkind, J. Silvio;
Wettschureck, Nina;
Offermanns, Stefan

Publication type:

Article

Commissureless acts as a substrate adapter in a conserved Nedd4 E3 ubiquitin ligase pathway to promote axon growth across the midline.

Published in:

eLife, 2025, p. 1

By:

Sullivan, Kelly G.;
Bashaw, Greg J.

Publication type:

Article

The TRIP12 E3 ligase induces SWI/SNF component BRG1-β-catenin interaction to promote Wnt signaling.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-60535-5

By:

Kassel, Sara;
Yuan, Kai;
Bunnag, Nawat;
Neitzel, Leif R.;
Lu, Wenhui;
Schwarzkopf, Anna;
Maines, Benjamin;
Loberg, Matthew A.;
Xu, George;
Adams, Amber;
McCray, Andrew D.;
Cho, Alex;
Rockouski, Mary;
Orton, Gemma;
Goldsmith, Lily;
Aronno, Md Mubtaseem Ahnaf;
Spencer, Zachary T.;
Khan, Omar M.;
Ye, Fei;
Williams, Charles

Publication type:

Article

Sequence rules for a long SPOP-binding degron required for protein ubiquitylation.

Published in:

Biochemical Journal, 2025, v. 482, n. 10, p. 583, doi. 10.1042/BCJ20253041

By:

Makhlouf, Linda;
Mishra, Mukul;
Makhlouf, Hannah;
Manfield, Iain;
Busino, Luca;
Zeqiraj, Elton

Publication type:

Article

ERK1-mediated GLYCTK2 phosphorylation promotes fructolysis to sustain glioblastoma survival under glucose deprivation.

Published in:

Cell Death Discovery, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41420-025-02544-3

By:

Li, Yingping;
Zhang, Fenna;
Hu, Fumin;
Tong, Rui;
Wen, Yueqi;
Fu, Guokai;
Bian, Xueli

Publication type:

Article

TRIM19 enhances the chemosensitivity of endometrial cancer by regulating the TBX2/NRF2 axis.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02717-7

By:

Ding, Ning;
Li, Yujiao;
Yu, Xiaohui

Publication type:

Article

Ubiquitin-SUMO tag-team wrestles acute promyelocytic leukemia.

Published in:

Journal of Cell Biology, 2025, v. 224, n. 6, p. 1, doi. 10.1083/jcb.202504010

By:

Vertegaal, Alfred C. O.

Publication type:

Article

PML mutants from arsenic-resistant patients reveal SUMO1-TOPORS and SUMO2/3-RNF4 degradation pathways.

Published in:

Journal of Cell Biology, 2025, v. 224, n. 6, p. 1, doi. 10.1083/jcb.202407133

By:

Jaffray, Ellis G.;
Tatham, Michael H.;
Mojsa, Barbara;
Plechanovová, Anna;
Rojas-Fernandez, Alejandro;
Liu, Julio C. Y.;
Mailand, Niels;
Ibrahim, Adel F. M.;
Ball, Graeme;
Porter, Iain M.;
Hay, Ronald T.

Publication type:

Article

Unleashing the Power of Covalent Drugs for Protein Degradation.

Published in:

Medicinal Research Reviews, 2025, v. 45, n. 4, p. 1045, doi. 10.1002/med.22101

By:

Fu, Meng‐Jie;
Jin, Hang;
Wang, Shao‐Peng;
Shen, Liang;
Liu, Hong‐Min;
Liu, Ying;
Zheng, Yi‐Chao;
Dai, Xing‐Jie

Publication type:

Article

The E3 ligase TRIM21 promotes progression of pancreatic ductal adenocarcinoma by down-regulating TAp63α and derepressing IL20RB.

Published in:

Science Signaling, 2025, v. 18, n. 889, p. 1, doi. 10.1126/scisignal.adv4579

By:

Li, Zejiao;
Gao, Fengwei;
Liu, Xuesha;
Fan, Shijie;
Qi, Yucheng;
He, Mingzhu;
Luo, Xiushuang;
Nie, Xiaoyun;
Wang, Jia;
Wang, Yajun;
Xiao, Zhi-Xiong Jim;
Li, Chenghua

Publication type:

Article

Evidence for trans-generational immune priming against Vibrio splendidus in the oyster Crassostrea gigas.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1536562

By:

Song, Xiaorui;
Wang, Weilin;
Dong, Miren;
Liu, Chang;
Yang, Chuanyan;
Wang, Lingling;
Song, Linsheng

Publication type:

Article

Structure-based design of potent and selective inhibitors of the HECT ligase NEDD4.

Published in:

Communications Chemistry, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42004-025-01557-4

By:

Maspero, Elena;
Cappa, Anna;
Weber, Janine;
Trifirò, Paolo;
Amici, Raffaella;
Bruno, Agostino;
Fagà, Giovanni;
Cecatiello, Valentina;
Fattori, Raimondo;
Leuzzi, Brian;
Taibi, Vincenzo;
Meroni, Giuseppe;
Pasi, Maurizio;
Romussi, Alessia;
Sartori, Luca;
Villa, Manuela;
Vultaggio, Stefania;
Cirò, Marco;
Soffientini, Paolo;
Lombardo, Lierin

Publication type:

Article

Functional Diversity of A-Type RING Ligases (ATL) Genes: Insights into the Crucial Roles of E3 Ubiquitin Ligases in Plant Biology.

Published in:

Journal of Plant Growth Regulation, 2025, v. 44, n. 5, p. 1827, doi. 10.1007/s00344-024-11547-w

By:

Sierra-Cacho, Daniel;
Méndez-Gómez, Manuel;
Aguilar-Hernández, Victor;
Guzmán, Plinio

Publication type:

Article

Regulatory Roles of E3 Ubiquitin Ligases and Deubiquitinases in Bone.

Published in:

Biomolecules (2218-273X), 2025, v. 15, n. 5, p. 679, doi. 10.3390/biom15050679

By:

He, Haotian;
Wang, Lifei;
Xian, Bao;
Xia, Yayi

Publication type:

Article

Overexpression in Plasmodium falciparum of an intrinsically disordered protein segment of Pf UT impairs the parasite's proteostasis and reduces its growth rate.

Published in:

Frontiers in Cellular & Infection Microbiology, 2025, p. 1, doi. 10.3389/fcimb.2025.1565814

By:

Avalos-Padilla, Yunuen;
Bouzón-Arnáiz, Inés;
Ramírez, Miriam;
Camarero-Hoyos, Claudia;
Orozco-Quer, Marc;
M. Arce, Elsa;
Muñoz-Torrero, Diego;
Fernàndez-Busquets, Xavier

Publication type:

Article

Design, Synthesis, Anticancer Evaluation and Molecular Docking of Pyrimidine, Pyrido[4,3-d]pyrimidine and 5,6,7,8-Tetrahydropyrido[3,4-d]pyrimidine Derivatives as Novel KRAS-G12D Inhibitors and PROTACs.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 5, p. 696, doi. 10.3390/ph18050696

By:

Yang, Hailong;
Gan, Lu;
Zhang, Huabei

Publication type:

Article

Genome-Wide Identification, Evolution and Expression Analysis of the U-Box E3 Ubiquitin Ligases Gene Family in Poplar (Populus alba × P. tremula var. glandulosa).

Published in:

Forests (19994907), 2025, v. 16, n. 5, p. 749, doi. 10.3390/f16050749

By:

Song, Bobo;
Wei, Qixuan;
Liu, Xudong;
Sun, Kexin;
Liao, Lingdou;
Zu, Anning;
Wei, Yifan;
Liu, Qian;
Fu, Fangfang;
Ming, Meiling

Publication type:

Article

The Function of TRIM25 in Antiviral Defense and Viral Immune Evasion.

Published in:

Viruses (1999-4915), 2025, v. 17, n. 5, p. 735, doi. 10.3390/v17050735

By:

Liu, Qianxun;
Peng, Shantong;
Wei, Jiani;
Xie, Zhenzhen

Publication type:

Article

A Brief Overview of the Epigenetic Regulatory Mechanisms in Plants.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4700, doi. 10.3390/ijms26104700

By:

Tresas, Theodoros;
Isaioglou, Ioannis;
Roussis, Andreas;
Haralampidis, Kosmas

Publication type:

Article

Membrane‐Bounded Intracellular E3 Ubiquitin Ligase‐Targeting Chimeras (MembTACs) for Targeted Membrane Protein Degradation.

Published in:

Angewandte Chemie, 2025, v. 137, n. 23, p. 1, doi. 10.1002/ange.202501857

By:

Mo, Mengwu;
Wang, Feiyu;
Zhang, Huiming;
Zhang, Ying;
Yang, Chaoyong;
Shang, Jinbiao;
Zhu, Zhi

Publication type:

Article

An insect symbiotic virus promotes the transmission of a phytoarbovirus via inhibiting E3 ubiquitin ligase Sina.

Published in:

PLoS Pathogens, 2025, v. 21, n. 5, p. 1, doi. 10.1371/journal.ppat.1013178

By:

Wang, Hui;
Zhang, Jieting;
Liu, Runfa;
Li, You;
Du, Yu;
Wei, Taiyun

Publication type:

Article

Clinical manifestations of Johanson-Blizzard syndrome in a patient with nucleotide variants in the UBR1 gene.

Published in:

Vojnosanitetski Pregled: Military Medical & Pharmaceutical Journal of Serbia, 2023, v. 88, n. 10, p. 885, doi. 10.2298/VSP220803003J

By:

Jojkić-Pavkov, Danijela;
Tošić, Jela;
Kavečan, Ivana;
Plazačić, Milica

Publication type:

Article

Histone monoubiquitination by Clock-Bmal1 complex marks Per1 and Per2 genes for circadian feedback.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 10, p. 759, doi. 10.1038/nsmb.3076

By:

Tamayo, Alfred G;
Duong, Hao A;
Robles, Maria S;
Mann, Matthias;
Weitz, Charles J

Publication type:

Article

Internal motions prime cIAP1 for rapid activation.

Published in:

Nature Structural & Molecular Biology, 2014, v. 21, n. 12, p. 1068, doi. 10.1038/nsmb.2916

By:

Phillips, Aaron H;
Schoeffler, Allyn J;
Matsui, Tsutomu;
Weiss, Thomas M;
Blankenship, John W;
Zobel, Kerry;
Giannetti, Anthony M;
Dueber, Erin C;
Fairbrother, Wayne J

Publication type:

Article

Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs.

Published in:

Nature Structural & Molecular Biology, 2014, v. 21, n. 9, p. 803, doi. 10.1038/nsmb.2874

By:

Chamberlain, Philip P;
Lopez-Girona, Antonia;
Miller, Karen;
Carmel, Gilles;
Pagarigan, Barbra;
Chie-Leon, Barbara;
Rychak, Emily;
Corral, Laura G;
Ren, Yan J;
Wang, Maria;
Riley, Mariko;
Delker, Silvia L;
Ito, Takumi;
Ando, Hideki;
Mori, Tomoyuki;
Hirano, Yoshinori;
Handa, Hiroshi;
Hakoshima, Toshio;
Daniel, Thomas O;
Cathers, Brian E

Publication type:

Article

PTEN is a protein tyrosine phosphatase for IRS1.

Published in:

Nature Structural & Molecular Biology, 2014, v. 21, n. 6, p. 522, doi. 10.1038/nsmb.2828

By:

Shi, Yuji;
Wang, Junru;
Chandarlapaty, Sarat;
Cross, Justin;
Thompson, Craig;
Rosen, Neal;
Jiang, Xuejun

Publication type:

Article

Plant ubiquitin ligases as signaling hubs.

Published in:

Nature Structural & Molecular Biology, 2014, v. 21, n. 4, p. 293, doi. 10.1038/nsmb.2804

By:

Shabek, Nitzan;
Zheng, Ning

Publication type:

Article

New insights into ubiquitin E3 ligase mechanism.

Published in:

Nature Structural & Molecular Biology, 2014, v. 21, n. 4, p. 301, doi. 10.1038/nsmb.2780

By:

Berndsen, Christopher E;
Wolberger, Cynthia

Publication type:

Article

JMJD1C demethylates MDC1 to regulate the RNF8 and BRCA1-mediated chromatin response to DNA breaks.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 12, p. 1425, doi. 10.1038/nsmb.2702

By:

Watanabe, Sugiko;
Watanabe, Kenji;
Akimov, Vyacheslav;
Bartkova, Jirina;
Blagoev, Blagoy;
Lukas, Jiri;
Bartek, Jiri

Publication type:

Article

Death control.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 10, p. 982, doi. 10.1038/nsmb.2408

By:

Montoya, Michelle

Publication type:

Article

NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 5, p. 511, doi. 10.1038/nsmb.2269

By:

Besten, Willem den;
Verma, Rati;
Kleiger, Gary;
Oania, Robert S;
Deshaies, Raymond J

Publication type:

Article

Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 2, p. 184, doi. 10.1038/nsmb.2231

By:

Dou, Hao;
Buetow, Lori;
Hock, Andreas;
Sibbet, Gary J;
Vousden, Karen H;
Huang, Danny T

Publication type:

Article

Cbl exposes its RING finger.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 2, p. 131, doi. 10.1038/nsmb.2241

By:

Kales, Stephen C;
Ryan, Philip E;
Lipkowitz, Stanley

Publication type:

Article

FBXL19 Targeted STK11 Degradation Enhances Cigarette Smoke-Induced Airway Epithelial Cell Cytotoxicity.

Published in:

COPD: Journal of Chronic Obstructive Pulmonary Disease, 2024, v. 21, n. 1, p. 1, doi. 10.1080/15412555.2024.2342797

By:

Li, Xiuying;
Lakshmi, Sowmya P.;
Uemasu, Kiyoshi;
Lane, Zachary;
Reddy, Rajan T.;
Chandra, Divay;
Zou, Chunbin;
Jiang, Yu;
Nyunoya, Toru

Publication type:

Article

HIV: Tagged for destruction.

Published in:

Nature Reviews Microbiology, 2012, v. 10, n. 2, p. 81, doi. 10.1038/nrmicro2739

By:

Molloy, Sheilagh

Publication type:

Article

Polymorphism of P53-Ets/ AP1 transactivation region of MDM2 oncogene and its immunohistochemical analysis in canine tumours.

Published in:

Veterinary & Comparative Oncology, 2016, v. 14, n. 2, p. 137, doi. 10.1111/vco.12080

By:

Rezaie, A.;
Tabandeh, M. R.;
Noori, S. M. A.

Publication type:

Article

A Buchwald–Hartwig Protocol to Enable Rapid Linker Exploration of Cereblon E3‐Ligase PROTACs**.

Published in:

Chemistry - A European Journal, 2020, v. 26, n. 70, p. 16818, doi. 10.1002/chem.202003137

By:

Hayhow, Thomas G.;
Borrows, Rachel E. A.;
Diène, Coura R.;
Fairley, Gary;
Fallan, Charlene;
Fillery, Shaun M.;
Scott, James S.;
Watson, David W.

Publication type:

Article

Mechanistic exploration of ubiquitination-mediated pathways in cerebral ischemic injury.

Published in:

Molecular Biology Reports, 2024, v. 52, n. 1, p. 1, doi. 10.1007/s11033-024-10123-5

By:

Khanra, Supriya;
Singh, Shareen;
Singh, Thakur Gurjeet

Publication type:

Article

Genome-wide analysis of gene expression profiling revealed that COP9 signalosome is essential for correct expression of Fe homeostasis genes in Arabidopsis.

Published in:

BioMetals, 2017, v. 30, n. 5, p. 685, doi. 10.1007/s10534-017-0036-8

By:

Eroglu, Seckin;
Aksoy, Emre

Publication type:

Article

Skp2 in the ubiquitin‐proteasome system: A comprehensive review.

Published in:

Medicinal Research Reviews, 2020, v. 40, n. 5, p. 1920, doi. 10.1002/med.21675

By:

Asmamaw, Moges Dessale;
Liu, Ying;
Zheng, Yi‐Chao;
Shi, Xiao‐Jing;
Liu, Hong‐Min

Publication type:

Article

Neur1 and Neur2 are required for hippocampus‐dependent spatial memory and synaptic plasticity.

Published in:

Hippocampus, 2020, v. 30, n. 11, p. 1158, doi. 10.1002/hipo.23247

By:

Lee, Jaehyun;
Yoon, Ki‐Jun;
Park, Pojeong;
Lee, Chaery;
Kim, Min Jung;
Han, Dae Hee;
Kim, Ji‐il;
Kim, Somi;
Lee, Hye‐Ryeon;
Lee, Yeseul;
Jang, Eun‐Hae;
Ko, Hyoung‐Gon;
Kong, Young‐Yun;
Kaang, Bong‐Kiun

Publication type:

Article

Deletion of newly described pro-survival molecule Pellino-1 increases oxidative stress, downregulates cIAP2/NF-κB cell survival pathway, reduces angiogenic response, and thereby aggravates tissue function in mouse ischemic models.

Published in:

Basic Research in Cardiology, 2020, v. 115, n. 4, p. 1, doi. 10.1007/s00395-020-0804-4

By:

Selvaraju, Vaithinathan;
Thirunavukkarasu, Mahesh;
Joshi, Mandip;
Oriowo, Babatunde;
Shaikh, Inam A.;
Rishi, Muhammad Tipu;
Tapias, Leonidas;
Coca-Soliz, Vladimir;
Saad, Ibnalwalid;
Campbell, Jacob;
Pradeep, Seetur R.;
Swaminathan, Santosh;
Yee, Siu-Pok;
McFadden, David W.;
Alexander Palesty, J.;
Maulik, Nilanjana

Publication type:

Article

Triad3A attenuates pathological cardiac hypertrophy involving the augmentation of ubiquitination-mediated degradation of TLR4 and TLR9.

Published in:

Basic Research in Cardiology, 2020, v. 115, n. 2, p. 1, doi. 10.1007/s00395-020-0779-1

By:

Lu, Xia;
He, Yijie;
Tang, Chao;
Wang, Xiaoyang;
Que, Linli;
Zhu, Guoqing;
Liu, Li;
Ha, Tuanzhu;
Chen, Qi;
Li, Chuanfu;
Xu, Yong;
Li, Jiantao;
Li, Yuehua

Publication type:

Article

Inhibition of the Arg/N-end rule pathway-mediated proteolysis by dipeptide-mimetic molecules.

Published in:

Amino Acids, 2016, v. 48, n. 1, p. 235, doi. 10.1007/s00726-015-2083-1

By:

Kitamura, Kenji

Publication type:

Article

Small ubiquitin-like modifiers E3 ligases in plant stress.

Published in:

Functional Plant Biology, 2024, v. 51, n. 5, p. 1, doi. 10.1071/FP24032

By:

Ghimire, Shantwana;
Hasan, Md Mahadi;
Xiang-Wen Fang

Publication type:

Article

The molecular events underpinning cultivar differences in melatonin counteracting salt damage in Phaseolus vulgaris.

Published in:

Functional Plant Biology, 2022, v. 49, n. 2, p. 201, doi. 10.1071/FP21126

By:

Han, Yiqiang;
Gao, Yamei;
Li, Ming;
Du, Yanli;
Zhang, Yuxian;
Zhang, Wenhui;
Du, Jidao

Publication type:

Article

Catalysis of non-canonical protein ubiquitylation by the ARIH1 ubiquitin ligase.

Published in:

Biochemical Journal, 2023, v. 480, n. 22, p. 1817, doi. 10.1042/BCJ20230373

By:

Purser, Nicholas;
Tripathi-Giesgen, Ishita;
Li, Jerry;
Scott, Daniel C.;
Horn-Ghetko, Daniel;
Baek, Kheewoong;
Schulman, Brenda A.;
Alpi, Arno F.;
Kleiger, Gary

Publication type:

Article

Overexpression of ARM repeat/U-box containing E3 ligase, PUB2 positively regulates growth and oxidative stress response in Arabidopsis.

Published in:

Biochemical Journal, 2023, v. 480, n. 9, p. 555, doi. 10.1042/BCJ20230026

By:

Saini, Lokesh K.;
Sharma, Manisha;
Ravi, Barkha;
Ghosh, Soma;
Pahuja, Sonam;
Singh, Nidhi;
Pandey, Girdhar K.

Publication type:

Article

Identification of ester-linked ubiquitylation sites during TLR7 signalling increases the number of inter-ubiquitin linkages from 8 to 12.

Published in:

Biochemical Journal, 2022, v. 479, n. 23, p. 2419, doi. 10.1042/BCJ20220510

By:

McCrory, Elisha H.;
Akimov, Vyacheslav;
Cohen, Philip;
Blagoev, Blagoy

Publication type:

Article