Works matching DE "DRUG target"

Results: 5000

Reprogramming of GM-CSF-dependent alveolar macrophages through GSK3 activity modulation.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.102659

By:

Ríos, Israel;
Herrero, Cristina;
Torres-Torresano, Mónica;
López-Navarro, Baltasar;
Teresa Schiaffino, María;
Díaz Crespo, Francisco;
Nieto-Valle, Alicia;
Samaniego, Rafael;
Sierra-Palomares, Yolanda;
Oliver, Eduardo;
Revuelta-Salgado, Fernando;
García-Luján, Ricardo;
Sánchez-Mateos, Paloma;
Delgado, Rafael;
Puig-Kröger, Amaya;
Corbí, Angel L.

Publication type:

Article

Transcriptional pattern enriched for synaptic signaling is associated with shorter survival of patients with high-grade serous ovarian cancer.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.101369

By:

Bhattacharya, Arkajyoti;
Stutvoet, Thijs S.;
Perla, Mirela;
Loipfinger, Stefan;
Jalving, Mathilde;
Reyners, Anna K. L.;
Vermeer, Paola D.;
Drapkin, Ronny;
de Bruyn, Marco;
de Vries, Elisabeth G. E.;
de Jong, Steven;
Fehrmann, Rudolf S. N.

Publication type:

Article

Thrombospondin‐1 binds to integrin β3 to inhibit vascular calcification through suppression of NF‐κB pathway.

Published in:

Journal of Pathology, 2025, v. 266, n. 1, p. 109, doi. 10.1002/path.6417

By:

Liu, Fang;
Liang, Qingchun;
Li, Li;
Gong, Yuan;
Li, Mingxi;
Feng, Liyun;
Chen, An;
Ye, Yuanzhi;
Lan, Zirong;
Li, Yining;
Ou, Jing‐Song;
Lu, Lihe;
Yan, Jianyun

Publication type:

Article

Contribution of alterations in peritubular capillary density and microcirculation to the progression of tubular injury and kidney fibrosis.

Published in:

Journal of Pathology, 2025, v. 266, n. 1, p. 95, doi. 10.1002/path.6414

By:

Ren, Zhengrong;
Shao, Fang;
Chen, Shuli;
Sun, Yanyan;
Ding, Zhi;
Dong, Lei;
Zhang, Junfeng;
Zang, Yuhui

Publication type:

Article

Interleukin‐11 expressed in the polyp‐enriched fibroblast subset is a potential therapeutic target in Peutz‐Jeghers syndrome.

Published in:

Journal of Pathology, 2025, v. 266, n. 1, p. 66, doi. 10.1002/path.6408

By:

Domènech‐Moreno, Eva;
Lim, Wei‐Wen;
Montrose, Melissa G;
Sévigny, Myriam;
Brandt, Anders;
Lemmetyinen, Toni T;
Viitala, Emma W;
Mäkelä, Tomi P;
Cook, Stuart A;
Ollila, Saara

Publication type:

Article

PacBio-based de novo transcriptomics of the coconut rhinoceros beetle Oryctes rhinoceros identifies physiologically important full-length genes and sheds insights into the molecular relationship (chitin synthase) between Scarabaeidae (Coleoptera) and Hymenoptera

Published in:

3 Biotech, 2025, v. 15, n. 6, p. 1, doi. 10.1007/s13205-025-04348-9

By:

Bhuvaragavan, Sreeramulu;
Sruthi, Kannan;
Nivetha, Ramanathan;
Keerthana, Chitti Babu;
Marieshwari, Balashanmuga Nehru;
Janarthanan, Sundaram

Publication type:

Article

Mendelian randomization analysis reveals the potential of the IKZF1 gene as a therapeutic target in colorectal cancer.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02683-0

By:

Lin, Junzuo;
Xu, Qian;
Zhao, Zhengfei

Publication type:

Article

Computational analysis of DEHP's oncogenic role in colorectal cancer.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02616-x

By:

Zhu, Zhou;
Qin, Jian;
He, Chungang;
Wang, Shuangyou;
Lu, Yaolin;
Wang, Shuai;
Zhong, Xiaogang

Publication type:

Article

Mast cells are key mediators in the pulmonary inflammatory response to formaldehyde exposure.

Published in:

Toxicological Sciences, 2025, v. 205, n. 1, p. 180, doi. 10.1093/toxsci/kfaf025

By:

Gibb, Matthew;
Reinert, Angela N;
Schedin, Troy;
Merrick, Daniel T;
Brown, Jared M;
Bauer, Alison K

Publication type:

Article

Matrix Remodeling Associated Genes (MXRAs): structural diversity, functional significance, and therapeutic potential in tumor microenvironments.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02728-4

By:

Zeng, Chao;
Lv, Xiao;
Wang, Feng;
Huang, Yaomin;
Ren, Yanxian;
Zhang, Hengwei

Publication type:

Article

HOX gene dysregulation in glioblastoma: a narrative review of current advances.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02684-z

By:

Hekim, Suleyman;
Bunda, Severa;
Dilibaerguli, Shaliman;
Palihati, Maierdan;
Mamatjan, Yasin

Publication type:

Article

Mendelian randomization analysis reveals the potential of the IKZF1 gene as a therapeutic target in colorectal cancer.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02683-0

By:

Lin, Junzuo;
Xu, Qian;
Zhao, Zhengfei

Publication type:

Article

Visfatin promotes multiple myeloma cell proliferation and inhibits apoptosis by inducing IL-6 production via NF-κB pathways.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02682-1

By:

Tie, Wenting;
Ma, Tao;
Liu, Jia;
Yi, Zhigang;
Xiong, Hao;
Bai, Jun;
Li, Yanhong;
Li, Lijuan;
Zhang, Liansheng

Publication type:

Article

Sphingolipid metabolism-related genes as diagnostic markers in pneumonia-induced sepsis: the AUG model.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-01150-8

By:

Wu, Jing;
Li, Xiaomin;
Chen, Zhihao;
Lin, Yiting;
Long, Qiuyue;
Jiang, Mingzheng;
Hu, Xiaoyi;
Song, Shixu;
Ye, Hongli;
Li, Jiwei;
Wu, Fangfang;
Zheng, Jianshi;
Wang, Minghui;
Gao, Zhancheng;
Ning, Pu;
Zheng, Yali

Publication type:

Article

Dual COX-2/TNF-α Inhibitors as Promising Anti-inflammatory and Cancer Chemopreventive Agents: A Review.

Published in:

IJ Pharmaceutical Research (IJPR), 2024, v. 23, n. 1, p. 1, doi. 10.5812/ijpr-151312

By:

Tajdari, Mobina;
Peyrovinasab, Amirreza;
Bayanati, Maryam;
Rabbani, Mohammad Ismail Mahboubi;
Abdolghaffari, Amir Hossein;
Zarghi, Afshin

Publication type:

Article

Near‐Infrared Chemiluminescent Theranostics.

Published in:

Angewandte Chemie, 2025, v. 137, n. 21, p. 1, doi. 10.1002/ange.202501681

By:

Lin, Youshi;
Huang, Jingsheng;
Pu, Kanyi

Publication type:

Article

Dihydroartemisinin Attenuates Radiation‐Induced Lung Injury by Inhibiting the cGAS/STING/NF‐κB Signaling Pathway.

Published in:

Drug Development Research, 2025, v. 86, n. 3, p. 1, doi. 10.1002/ddr.70090

By:

Wang, Cailan;
Lin, Xinyi;
Guan, Shichun;
Wu, Qiaoyuan;
Liang, Shixiong

Publication type:

Article

miR‐338‐3p Targets SIRT6 to Inhibit Liver Cancer Malignancy and Paclitaxel Resistance.

Published in:

Drug Development Research, 2025, v. 86, n. 3, p. 1, doi. 10.1002/ddr.70089

By:

Huang, Yiyuan;
Huang, Sunhui;
Li, Quan;
Zhang, Hongchang;
Xiao, Wei;
Chen, Yunhui

Publication type:

Article

Upregulated Expression of SHMT2 Predicts Poor Survival of Lung Adenocarcinoma.

Published in:

Genetics Research, 2025, v. 2025, p. 1, doi. 10.1155/genr/6104753

By:

Guo, Qi;
Huang, Guang-Hong;
Chen, Pu;
Guo, Chao;
Liu, Hongda

Publication type:

Article

PHARMACOKINETICS AND PHARMACODYNAMICS PREDICTED PROFILES OF STRIGOLACTONES - BIOINFORMATICS APPROACHES.

Published in:

Romanian Journal of Biophysics, 2025, v. 35, n. 1, p. 1, doi. 10.59277/RJB.2025.1.01

By:

PĂUN, ANDRA MARIA;
TRÎMBIȚAȘ, S.;
MERNEA, MARIA;
AVRAM, SPERANțA

Publication type:

Article

Molecular Tissue Profiling in a Clinically Selected Pancreatic Cancer Cohort.

Published in:

Oncology Research & Treatment, 2025, v. 48, n. 5, p. 256, doi. 10.1159/000543997

By:

Hegenberg, Stefanie;
Germing, Tobias;
Schlageter, Elena;
Ekmekciu, Ira;
Christmann, Jens;
Tannapfel, Andrea;
Reinacher-Schick, Anke

Publication type:

Article

Assessment of MXD3 Expression as a Predictor of Survival in Lung Squamous Cell Carcinoma.

Published in:

International Journal of Genomics, 2025, v. 2025, p. 1, doi. 10.1155/ijog/7355595

By:

Cao, Mingzhi;
Zhang, Ning;
Chen, Tangbing;
Jiang, Hong;
Liu, Hongda

Publication type:

Article

Acute administration of lovastatin had no pronounced effect on motor abilities, motor coordination, gait nor simple cognition in a mouse model of Angelman syndrome.

Published in:

Journal of Neurodevelopmental Disorders, 2025, v. 17, n. 1, p. 1, doi. 10.1186/s11689-025-09616-6

By:

Fenton, Timothy A.;
Petkova, Stela P.;
Adhikari, Anna;
Silverman, Jill L.

Publication type:

Article

Metrnl/IL-41 Alleviates Lipopolysaccharide-Induced Acute Lung Injury by Suppressing Inflammatory Responses through the AMPK/SIRT1 Signaling Pathway.

Published in:

International Archives of Allergy & Immunology, 2025, v. 186, n. 5, p. 496, doi. 10.1159/000542112

By:

Wang, Guannan;
Liu, Danqin;
Zhang, Kejing;
Wang, Yan;
Xu, Zhiwei

Publication type:

Article

Inhibition of DLK1 regulates AT2 differentiation and alleviates established pulmonary fibrosis by upregulating TTF-1/CLDN6.

Published in:

Respiratory Research, 2025, v. 26, n. 1, p. 1, doi. 10.1186/s12931-025-03264-z

By:

Li, Yinzhen;
Zhou, Chen;
Sun, Jiaxing;
Wang, Enhao;
Wang, Chunmei;
Liu, Xuan;
Zhou, Xiaohui;
Bai, Jianwen

Publication type:

Article

Integrating multi-omics data to identify the role of Aggrephagy-related genes in tumor microenvironment and key tumorigenesis factors of GB from the perspective of single-cell sequencing.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02431-4

By:

Chen, Zipei;
Zhang, Shengke;
Jiang, Chenglu;
Jiang, Lai;
Chen, Haiqing;
Huang, Jinbang;
Liu, Jie;
Yang, Guanhu;
Luo, Xiufang;
Chi, Hao;
Fu, Jiangping

Publication type:

Article

TCoCPIn reveals topological characteristics of chemical protein interaction networks for novel feature discovery.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-01410-7

By:

Wang, Jianshi;
Ohsawa, Yukio

Publication type:

Article

Synthesis and evaluation of quinolinvinyl-phenoxy-1,2,3-triazole-acetamide hybrids against breast cancer.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-01051-w

By:

Safavi, Maliheh;
Iraji, Aida;
Farid, Sara Moghadam;
Mahdavi, Mohammad;
Fattaheian-Dehkordi, Samaneh;
Akbarzadeh, Tahmineh;
Saeedi, Mina

Publication type:

Article

Expression and Clinical Significance of CXCR5 and LAG‐3 on Peripheral Blood CD8<sup>+</sup> T Cells in Patients With Diffuse Large B‐Cell Lymphoma.

Published in:

Kaohsiung Journal of Medical Sciences, 2025, v. 41, n. 5, p. 1, doi. 10.1002/kjm2.70005

By:

Guo, Xi‐Zhe;
Guo, Ya‐Fei;
Wu, Shi‐Xin

Publication type:

Article

Exploring potential diagnostic markers and therapeutic targets for type 2 diabetes mellitus with major depressive disorder through bioinformatics and in vivo experiments.

Published in:

Discover Mechanical Engineering, 2025, v. 4, n. 1, p. 1, doi. 10.1038/s41598-025-01175-z

By:

Zhang, Yikai;
Wu, Linyue;
Zheng, Chuanjie;
Xu, Huihui;
Lin, Weiye;
Chen, Zheng;
Cao, Lingyong;
Qu, Yiqian

Publication type:

Article

ゲノム医療と前立腺癌 ― 現状と未来の展望 ―.

Published in:

Nishinihon Journal of Urology, 2025, v. 87, n. 4, p. 167

By:

土肥洋一郎

Publication type:

Article

根治切除不能な局所進行性および転移性尿路上皮癌におけるゲノム医療.

Published in:

Nishinihon Journal of Urology, 2025, v. 87, n. 4, p. 165

By:

鑪野秀一;
榎田英樹

Publication type:

Article

Lit-OTAR framework for extracting biological evidences from literature Open Access.

Published in:

Bioinformatics, 2025, v. 41, n. 4, p. 1, doi. 10.1093/bioinformatics/btaf113

By:

Tirunagari, Santosh;
Saha, Shyamasree;
Venkatesan, Aravind;
Suveges, Daniel;
Carmona, Miguel;
Buniello, Annalisa;
Ochoa, David;
McEntyre, Johanna;
McDonagh, Ellen;
Harrison, Melissa

Publication type:

Article

Network Pharmacology and Molecular Docking to Identify the Molecular Targets of Novel Indole-quinoline Derivative in Cancer.

Published in:

Oriental Journal of Chemistry, 2025, v. 41, n. 1, p. 44, doi. 10.13005/ojc/410105

By:

MISHRA, SHOBHIT;
SACHDEVA, MONIKA;
NIMESH, HEMLATA

Publication type:

Article

Neutrophilic inflammation in bronchiectasis.

Published in:

European Respiratory Review, 2025, v. 34, n. 176, p. 1, doi. 10.1183/16000617.0179-2024

By:

Chalmers, James D.;
Metersky, Mark;
Aliberti, Stefano;
Morgan, Lucy;
Fucile, Sebastian;
Lauterio, Melanie;
McDonald, Patrick P.

Publication type:

Article

Advancing precision oncology with AI-powered genomic analysis.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1591696

By:

Srivastava, Ruby

Publication type:

Article

Identifying potential novel widespread determinants of bacterial pathogenicity using phylogenetic-based orthology analysis.

Published in:

Frontiers in Microbiology, 2025, p. 1, doi. 10.3389/fmicb.2025.1494490

By:

Ribeiro, Sara;
Alves, Karine;
Nourikyan, Julien;
Lavergne, Jean-Pierre;
de Bernard, Simon;
Buffat, Laurent

Publication type:

Article

Integrative single-cell RNA sequencing and bulk RNA sequencing reveals the characteristics of glutathione metabolism and protective role of GSTA4 gene in pancreatic cancer.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1571431

By:

Jia, Xinya;
Zhang, Qiang;
Wang, Zhe;
Cao, Jianliang;
Song, Anran;
Lan, Chao;
Hu, Yuepeng

Publication type:

Article

Chemotherapy Resistance Status of Common Human Pathogenic Protozoa.

Published in:

Advancements of Microbiology, 2025, v. 64, n. 1, p. 24, doi. 10.2478/am-2025-0002

By:

Baakdah, Fadi M.

Publication type:

Article

Fragment-based drug discovery for transthyretin kinetic stabilisers using a novel capillary zone electrophoresis method.

Published in:

PLoS ONE, 2025, v. 20, n. 5, p. 1, doi. 10.1371/journal.pone.0323816

By:

Chen, Wenjie

Publication type:

Article

Synthesis of Diversely Substituted Diethyl (Pyrrolidin-2-Yl)Phosphonates.

Published in:

Molecules, 2025, v. 30, n. 9, p. 2078, doi. 10.3390/molecules30092078

By:

Bagán, Andrea;
López-Ruiz, Alba;
Abás, Sònia;
Molins, Elies;
Pérez, Belén;
Muneta-Arrate, Itziar;
Callado, Luis F.;
Escolano, Carmen

Publication type:

Article

Research Progress on the Therapeutic Mechanisms of Stigmasterol for Multiple Diseases.

Published in:

Molecules, 2025, v. 30, n. 9, p. 1874, doi. 10.3390/molecules30091874

By:

Li, Juan;
Zheng, Xinhua;
Qi, Jinxu

Publication type:

Article

PCSK9 Inhibitors "Fast Track" Use Versus "Stepwise" Lipid-Lowering Therapy in Patients with Acute Coronary Syndrome: A Retrospective Single-Center Study in a "Real-World" Population.

Published in:

Journal of Clinical Medicine, 2025, v. 14, n. 9, p. 2992, doi. 10.3390/jcm14092992

By:

D'Andrea, Davide;
Capone, Valentina;
Bellis, Alessandro;
Castaldo, Rossana;
Franzese, Monica;
Carpinella, Gerardo;
Furbatto, Fulvio;
La Rocca, Fulvio;
Marsico, Fabio;
Marfella, Raffaele;
Paolisso, Giuseppe;
Paolisso, Pasquale;
Fumagalli, Carlo;
Cappiello, Maurizio;
Bossone, Eduardo;
Mauro, Ciro

Publication type:

Article

Identification of a Highly Virulent Verticillium nonalfalfae Strain Vn011 and Expression Analysis of Its Orphan Genes During Potato Inoculation.

Published in:

Plants (2223-7747), 2025, v. 14, n. 9, p. 1281, doi. 10.3390/plants14091281

By:

Wan, Mengyuan;
Chen, Xinlong;
Yi, Xiaoxi;
Fu, Yi;
Jin, Yuanliang;
Lyu, Dianqiu

Publication type:

Article

Proteomics-Based Investigation of Sexual Dimorphism in Swim Bladder Texture of Chu's Croaker (Nibea coibor).

Published in:

Foods, 2025, v. 14, n. 9, p. 1586, doi. 10.3390/foods14091586

By:

Zhang, Haoran;
Lin, Jiali;
Guo, Haoji;
He, Xianda;
Jiang, Wanying;
Yan, Lin;
Yan, Kuoqiu;
Wen, Xiaobo;
Lin, Fan

Publication type:

Article

Hydrazonate‐Based Copper(II) Metallodrugs: Insights into Solution Behavior, G‐Quadruplex DNA Interaction, and Anticancer Potential.

Published in:

Chemistry - An Asian Journal, 2025, v. 20, n. 9, p. 1, doi. 10.1002/asia.202401628

By:

Mohanty, Monalisa;
Lima, Sudhir;
Das Pattanayak, Pratikshya;
Das, Sanchita;
Buchholz, Axel;
Görls, Helmar;
Plass, Winfried;
Kaminsky, Werner;
Dinda, Rupam

Publication type:

Article

Combination of RNA-sequencing data analysis, network pharmacology, molecular docking techniques to investigate the mechanism of Prunella vulgaris L. in the treatment of non-small cell lung cancer.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02563-7

By:

Dan, Yanggang;
Jin, Yangli;
Wang, Jing;
Wang, Lu;
Zheng, Dawei

Publication type:

Article

PTTG1 promotes M2 macrophage polarization via the cGMP-PKG signaling pathway and facilitates EMT progression in human epithelial ovarian cancer cells.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02512-4

By:

Tian, Liang;
Liu, Liyun;
Wang, Chunlou;
Kong, Yan;
Miao, Zhigang;
Yao, Qing;
Zhang, He;
Li, Yuehong

Publication type:

Article

An integrative analysis combining bioinformatics, network pharmacology and experimental methods identified key genes of EGCG targets in Nasopharyngeal Carcinoma.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02365-x

By:

Yang, Yuhang;
Luo, Wenqi;
Feng, Zhang;
Chen, Xiaoyu;
Li, Jinqing;
Zuo, Long;
Duan, Meijiao;
He, Xiaosong;
Wang, Wenhua;
He, Feng;
Liu, Fangxian

Publication type:

Article

SF3a1: A Novel Potential Tumor Biomarker or Therapeutic Target.

Published in:

Journal of Cancer, 2025, v. 16, n. 7, p. 2353, doi. 10.7150/jca.103209

By:

Xueqian Shuai;
Yaoqi Sun;
Shupeng Liu;
Zhongping Cheng

Publication type:

Article