Works matching DE "BROMODOMAIN-containing proteins"
Results: 246
Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation.
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- Nature Structural & Molecular Biology, 2013, v. 20, n. 9, p. 1040, doi. 10.1038/nsmb.2642
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Druggability of methyl-lysine binding sites.
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- Journal of Computer-Aided Molecular Design, 2011, v. 25, n. 12, p. 1171, doi. 10.1007/s10822-011-9505-2
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Oncogenic super-enhancers in cancer: mechanisms and therapeutic targets.
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- Cancer & Metastasis Reviews, 2023, v. 42, n. 2, p. 471, doi. 10.1007/s10555-023-10103-4
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BET inhibitor resistance emerges from leukaemia stem cells.
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- Nature, 2015, v. 525, n. 7570, p. 538, doi. 10.1038/nature14888
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Transcriptional plasticity promotes primary and acquired resistance to BET inhibition.
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- Nature, 2015, v. 525, n. 7570, p. 543, doi. 10.1038/nature14898
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Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer.
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- Nature, 2014, v. 510, n. 7504, p. 278, doi. 10.1038/nature13229
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The bromodomain protein Brd4 insulates chromatin from DNA damage signalling.
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- Nature, 2013, v. 498, n. 7453, p. 246, doi. 10.1038/nature12147
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Reproductive biology: Molecule blocks sperm production.
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- Nature, 2012, v. 488, n. 7412, p. 432, doi. 10.1038/488432d
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TRIM24 links a non-canonical histone signature to breast cancer.
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- Nature, 2010, v. 468, n. 7326, p. 927, doi. 10.1038/nature09542
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Histone reader BRWD1 targets and restricts recombination to the Igk locus.
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- Nature Immunology, 2015, v. 16, n. 10, p. 1094, doi. 10.1038/ni.3249
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Inflammation super-enhancers.
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- Nature Immunology, 2014, v. 15, n. 12, p. 1103, doi. 10.1038/ni.3042
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Maintenance of macrophage transcriptional rograms and intestinal homeostasis by epigenetic reader SP140.
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- Science Immunology, 2017, v. 2, n. 9, p. 1, doi. 10.1126/sciimmunol.aag3160
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Two structurally distinct domains of the nucleoporin Nup170 cooperate to tether a subset of nucleoporins to nuclear pores.
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- Journal of Cell Biology, 2009, v. 185, n. 3, p. 387, doi. 10.1083/jcb.200810016
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Epigenetic Reader Bromodomain-Containing Protein 4 in Aging-Related Vascular Pathologies and Diseases: Molecular Basis, Functional Relevance, and Clinical Potential.
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- Biomolecules (2218-273X), 2023, v. 13, n. 7, p. 1135, doi. 10.3390/biom13071135
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Dopamine Transporter Knockout Rats Display Epigenetic Alterations in Response to Cocaine Exposure.
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- Biomolecules (2218-273X), 2023, v. 13, n. 7, p. 1107, doi. 10.3390/biom13071107
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Bromodomain-containing Protein 4 regulates innate inflammation via modulation of alternative splicing.
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- Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1212770
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Protein post-translational modification in SARS-CoV-2 and host interaction.
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- Frontiers in Immunology, 2023, v. 13, p. 1, doi. 10.3389/fimmu.2022.1068449
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Targeting BRD4 attenuates the stemness and aggressiveness of ameloblastoma.
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- Oral Diseases, 2024, v. 30, n. 5, p. 3212, doi. 10.1111/odi.14762
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Nanovesicles loaded with a TGF-β receptor 1 inhibitor overcome immune resistance to potentiate cancer immunotherapy.
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- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-39035-x
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Control of NF- kB activity in human melanoma by bromodomain and extra-terminal protein inhibitor I- BET151.
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- Pigment Cell & Melanoma Research, 2014, v. 27, n. 6, p. 1126, doi. 10.1111/pcmr.12282
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A convenient one-pot synthesis of novel heterocyclic systems of 9-chloro-4-methyl-6,11-dihydro-5H-benzo[b]pyrimido[4,5-e][1,4]diazepine and inhibitory evaluation against bromodomain-containing protein 4 (BRD4) enzyme by molecular docking.
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- Journal of the Iranian Chemical Society, 2023, v. 20, n. 11, p. 2841, doi. 10.1007/s13738-023-02880-0
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BRD4 facilitates osteogenic differentiation of human bone marrow mesenchymal stem cells through WNT4/NF-κB pathway.
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- Journal of Orthopaedic Surgery & Research, 2023, v. 18, n. 1, p. 1, doi. 10.1186/s13018-023-04335-x
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Spinal-Specific Super Enhancer in Neuropathic Pain.
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- Journal of Neuroscience, 2023, v. 43, n. 49, p. 8547, doi. 10.1523/JNEUROSCI.1006-23.2023
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Bromodomain-Containing Protein 9 Regulates Signaling Pathways and Reprograms the Epigenome in Immortalized Human Uterine Fibroid Cells.
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- International Journal of Molecular Sciences, 2024, v. 25, n. 2, p. 905, doi. 10.3390/ijms25020905
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BRD4 as a Therapeutic Target in Pulmonary Diseases.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 17, p. 13231, doi. 10.3390/ijms241713231
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BRD4 Inhibition Enhances the Antitumor Effects of Radiation Therapy in a Murine Breast Cancer Model.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 17, p. 13062, doi. 10.3390/ijms241713062
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Molecular Dynamics Simulations Combined with Markov Model to Explore the Effect of Allosteric Inhibitor Binding on Bromodomain-Containing Protein 4.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 13, p. 10831, doi. 10.3390/ijms241310831
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BRM Complex in Arabidopsis Adopts ncBAF-like Composition and Requires BRD Subunits for Assembly and Stability.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 4, p. 3917, doi. 10.3390/ijms24043917
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Mutation of Basic Residues R283, R286, and K288 in the Matrix Protein of Newcastle Disease Virus Attenuates Viral Replication and Pathogenicity.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 2, p. 980, doi. 10.3390/ijms24020980
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BRD9 Inhibition, Alone or in Combination with Cytostatic Compounds as a Therapeutic Approach in Rhabdoid Tumors.
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- International Journal of Molecular Sciences, 2017, v. 18, n. 7, p. 1537, doi. 10.3390/ijms18071537
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The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous Proteins.
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- International Journal of Molecular Sciences, 2016, v. 17, n. 11, p. 1849, doi. 10.3390/ijms17111849
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Fibronectin type III domain containing protein 5/irisin alleviated sepsis-induced acute kidney injury by abating ferroptosis through the adenosine 5'-monophosphate-activated protein kinase/nuclear factor erythroid-2-related factor 2 signaling pathway.
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- CytoJournal, 2024, v. 21, p. 1, doi. 10.25259/Cytojournal_62_2024
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Chromatin remodeling controls Kaposi's sarcoma-associated herpesvirus reactivation from latency.
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- PLoS Pathogens, 2018, v. 14, n. 9, p. 1, doi. 10.1371/journal.ppat.1007267
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Characterisation of different types of dispersoids present in homogenised Al-4·5Zn-1Mg alloy containing Zr, Cr and Mn.
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- Materials Science & Technology, 2011, v. 27, n. 8, p. 1294, doi. 10.1179/026708310X12635619988267
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A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced-Fit Pocket Stabilized by a Cation-π Interaction.
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- Angewandte Chemie, 2014, v. 126, n. 24, p. 6240, doi. 10.1002/ange.201402750
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4-Acyl Pyrroles: Mimicking Acetylated Lysines in Histone Code Reading.
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- Angewandte Chemie, 2013, v. 125, n. 52, p. 14305, doi. 10.1002/ange.201307652
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Bromodomain Drug Discovery – the Past, the Present, and the Future.
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- Chemical Record, 2018, v. 18, n. 12, p. 1808, doi. 10.1002/tcr.201800074
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BRD4 inhibitors broadly promote erastin-induced ferroptosis in different cell lines by targeting ROS and FSP1.
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- Discover Oncology, 2024, v. 15, n. 1, p. 1, doi. 10.1007/s12672-024-00928-y
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PEGylated dendritic nanoarchitechture improves mean survival time of BDF<sub>1</sub> mice bearing myelogenous k -562 leukemia.
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- Journal of Acute Disease, 2013, v. 2, n. 4, p. 327, doi. 10.1016/S2221-6189(13)60153-5
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Registered report: Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukemia.
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- eLife, 2015, p. 1, doi. 10.7554/eLife.08997
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Registered report: BET bromodomain inhibition as a therapeutic strategy to target c-Myc.
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- eLife, 2015, p. 1, doi. 10.7554/eLife.07072
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The Role of Bromodomain Testis-Specific Factor, BRDT, in Cancer: A Biomarker and A Possible Therapeutic Target.
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- Cell Journal (Yakhteh), 2017, v. 19, p. 1, doi. 10.22074/cellj.2017.5060
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NIT2 dampens BRD1 phase separation and restrains oxidative phosphorylation to enhance chemosensitivity in gastric cancer.
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- Science Translational Medicine, 2024, v. 16, n. 774, p. 1, doi. 10.1126/scitranslmed.ado8333
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BRD4 sustains p63 transcriptional program in keratinocytes.
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- Biology Direct, 2024, v. 19, n. 1, p. 1, doi. 10.1186/s13062-024-00547-1
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Enhancement of BDNF Expression and Memory by HD AC Inhibition Requires BET Bromodomain Reader Proteins.
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- Journal of Neuroscience, 2019, v. 39, n. 4, p. 612, doi. 10.1523/JNEUROSCI.1604-18.2018
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Epigenetic Readers of Lysine Acetylation Regulate Cocaine-Induced Plasticity.
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- Journal of Neuroscience, 2015, v. 35, n. 45, p. 15062, doi. 10.1523/JNEUROSCI.0826-15.2015
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A Novel Predicted Bromodomain-Related Protein Affects Coordination Between Meiosis and Spermiogenesis in Drosophila and Is Required for Male Meiotic Cytokinesis.
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- DNA & Cell Biology, 2010, v. 29, n. 9, p. 487, doi. 10.1089/dna.2009.0989
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Construction of the bromodomain-containing protein-associated prognostic model in triple-negative breast cancer.
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- Cancer Cell International, 2025, v. 25, n. 1, p. 1, doi. 10.1186/s12935-025-03648-7
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Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de-differentiated state.
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- Molecular Systems Biology, 2017, v. 13, n. 1, p. n/a, doi. 10.15252/msb.20166796
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BET Family Protein BRD4: An Emerging Actor in NFκB Signaling in Inflammation and Cancer.
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- Biomedicines, 2018, v. 6, n. 1, p. 16, doi. 10.3390/biomedicines6010016
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