Works matching DE "KINASE inhibitors"
Results: 3221
Notch is a direct negative regulator of the DNA-damage response.
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- Nature Structural & Molecular Biology, 2015, v. 22, n. 5, p. 417, doi. 10.1038/nsmb.3013
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- Article
Elevated serum thymidine kinase activity in canine splenic hemangiosarcoma<sup>*</sup> Elevated serum thymidine kinase activity in canine splenic hemangiosarcoma.
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- Veterinary & Comparative Oncology, 2012, v. 10, n. 4, p. 292, doi. 10.1111/j.1476-5829.2011.00298.x
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- Article
A Phosphoramidate Prodrug Platform: One‐Pot Amine Functionalization of Kinase Inhibitors with Oligoethylene Glycol for Improved Water‐Solubility.
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- Chemistry - A European Journal, 2024, v. 30, n. 49, p. 1, doi. 10.1002/chem.202401781
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- Article
Cover Feature: Optimization of the Lead Compound NVP‐BHG712 as a Colorectal Cancer Inhibitor (Chem. Eur. J. 23/2023).
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- Chemistry - A European Journal, 2023, v. 29, n. 23, p. 1, doi. 10.1002/chem.202300918
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- Article
Elucidating the potential effects of point mutations on FGFR3 inhibitor resistance via combined molecular dynamics simulation and community network analysis.
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- Journal of Computer-Aided Molecular Design, 2023, v. 37, n. 7, p. 325, doi. 10.1007/s10822-023-00510-8
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- Article
Target identification for repurposed drugs active against SARS-CoV-2 via high-throughput inverse docking.
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- Journal of Computer-Aided Molecular Design, 2022, v. 36, n. 1, p. 25, doi. 10.1007/s10822-021-00432-3
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- Article
A new method for estimating the relative binding free energy, derived from a free energy variational principle for the Pim-1-kinase–ligand and FKBP–ligand systems.
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- Journal of Computer-Aided Molecular Design, 2020, v. 34, n. 6, p. 647, doi. 10.1007/s10822-020-00302-4
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- Article
Identification and neuroprotective evaluation of a potential c-Jun N-terminal kinase 3 inhibitor through structure-based virtual screening and in-vitro assay.
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- Journal of Computer-Aided Molecular Design, 2020, v. 34, n. 6, p. 671, doi. 10.1007/s10822-020-00297-y
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- Article
Predicting octanol/water partition coefficients for the SAMPL6 challenge using the SM12, SM8, and SMD solvation models.
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- Journal of Computer-Aided Molecular Design, 2020, v. 34, n. 5, p. 575, doi. 10.1007/s10822-020-00293-2
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- Article
Octanol–water partition coefficient measurements for the SAMPL6 blind prediction challenge.
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- Journal of Computer-Aided Molecular Design, 2020, v. 34, n. 4, p. 405, doi. 10.1007/s10822-019-00271-3
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- Article
Data structures for computational compound promiscuity analysis and exemplary applications to inhibitors of the human kinome.
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- Journal of Computer-Aided Molecular Design, 2020, v. 34, n. 1, p. 1, doi. 10.1007/s10822-019-00266-0
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- Article
Systematic computational identification of promiscuity cliff pathways formed by inhibitors of the human kinome.
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- Journal of Computer-Aided Molecular Design, 2019, v. 33, n. 6, p. 559, doi. 10.1007/s10822-019-00198-9
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- Article
pK<sub>a</sub> measurements for the SAMPL6 prediction challenge for a set of kinase inhibitor-like fragments.
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- Journal of Computer-Aided Molecular Design, 2018, v. 32, n. 10, p. 1117, doi. 10.1007/s10822-018-0168-0
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- Article
Identification of novel inhibitors for Pim-1 kinase using pharmacophore modeling based on a novel method for selecting pharmacophore generation subsets.
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- Journal of Computer-Aided Molecular Design, 2016, v. 30, n. 1, p. 39, doi. 10.1007/s10822-015-9887-7
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- Article
Combining docking-based comparative intermolecular contacts analysis and k-nearest neighbor correlation for the discovery of new check point kinase 1 inhibitors.
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- Journal of Computer-Aided Molecular Design, 2015, v. 29, n. 6, p. 561, doi. 10.1007/s10822-015-9848-1
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- Article
Gastrointestinal stromal tumor: a review of current and emerging therapies.
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- Cancer & Metastasis Reviews, 2021, v. 40, n. 2, p. 625, doi. 10.1007/s10555-021-09961-7
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- Article
Pre-transplant utilization of sorafenib is not associated with increased complications after liver transplantation.
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- Transplant International, 2013, v. 26, n. 7, p. 734, doi. 10.1111/tri.12117
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- Article
Rho kinase inhibitors—a review on the physiology and clinical use in Ophthalmology.
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- Graefe's Archive of Clinical & Experimental Ophthalmology, 2019, v. 257, n. 6, p. 1101, doi. 10.1007/s00417-019-04283-5
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- Article
Effects of ripasudil, a rho kinase inhibitor, on blood flow in the optic nerve head of normal rats.
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- Graefe's Archive of Clinical & Experimental Ophthalmology, 2019, v. 257, n. 2, p. 303, doi. 10.1007/s00417-018-4191-6
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- Article
RKI-1447, a Rho kinase inhibitor, causes ocular hypotension, actin stress fiber disruption, and increased phagocytosis.
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- Graefe's Archive of Clinical & Experimental Ophthalmology, 2019, v. 257, n. 1, p. 101, doi. 10.1007/s00417-018-4175-6
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- Article
Anti-tumour activity of phosphoinositide-3-kinase antagonist AEZS-126 in models of ovarian cancer.
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- Archives of Gynecology & Obstetrics, 2015, v. 291, n. 1, p. 131, doi. 10.1007/s00404-014-3389-z
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- Article
Sequential combination of flavopiridol with Taxol synergistically suppresses human ovarian carcinoma growth.
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- Archives of Gynecology & Obstetrics, 2015, v. 291, n. 1, p. 143, doi. 10.1007/s00404-014-3408-0
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- Article
Aurora kinase inhibitor AZD1152 has an additional effect of platinum on a sequential application at the human ovarian cancer cell line SKOV3.
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- Archives of Gynecology & Obstetrics, 2013, v. 288, n. 1, p. 173, doi. 10.1007/s00404-013-2719-x
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- Article
Pediatric bithalamic gliomas have a distinct epigenetic signature and frequent EGFR exon 20 insertions resulting in potential sensitivity to targeted kinase inhibition.
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- Acta Neuropathologica, 2020, v. 139, n. 6, p. 1071, doi. 10.1007/s00401-020-02155-5
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- Article
Mediator kinase inhibition further activates super-enhancer-associated genes in AML.
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- Nature, 2015, v. 526, n. 7572, p. 273, doi. 10.1038/nature14904
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- Article
REV7 counteracts DNA double-strand break resection and affects PARP inhibition.
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- Nature, 2015, v. 521, n. 7553, p. 541, doi. 10.1038/nature14328
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- Article
Drug development: Mix and match.
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- Nature, 2015, v. 521, n. 7551, p. S12, doi. 10.1038/521S12a
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- Article
Therapy-induced tumour secretomes promote resistance and tumour progression.
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- Nature, 2015, v. 520, n. 7547, p. 368, doi. 10.1038/nature14336
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- Article
Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemia.
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- Nature, 2014, v. 513, n. 7519, p. 512, doi. 10.1038/nature13495
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- Article
Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy.
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- Nature, 2012, v. 489, n. 7414, p. 155, doi. 10.1038/nature11303
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- Article
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
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- Nature, 2012, v. 487, n. 7408, p. 505, doi. 10.1038/nature11249
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- Article
Chemical genetic discovery of targets and anti-targets for cancer polypharmacology.
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- Nature, 2012, v. 486, n. 7401, p. 80, doi. 10.1038/nature11127
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- Article
Upadacitinib therapy as a successful treatment of severe atopic dermatitis in a patient with a previous dupilumab-induced exanthematous drug reaction.
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- 2024
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- Case Study
Reverse engineering of drug induced DNA damage response signalling pathway reveals dual outcomes of ATM kinase inhibition.
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- BioDiscovery, 2017, p. 1, doi. 10.7750/BioDiscovery.2013.9.4
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- Article
Phosphorylase Kinase Inhibition Therapy in Burns and Scalds.
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- BioDiscovery, 2017, p. 1, doi. 10.3897/biodiscovery.20.e11207
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- Article
Comparable Outcomes of Pre-Versus Post-Tyrosine Kinase Inhibitor Era Treatment in Chronic Myeloid Leukemia: A Retrospective Cohort Study With Long-term Follow-up.
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- Cell Transplantation, 2023, v. 32, p. 1, doi. 10.1177/09636897231163212
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- Article
TCR signaling: the barrier within.
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- Nature Immunology, 2014, v. 15, n. 2, p. 136, doi. 10.1038/ni.2811
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- Article
Virus-induced autophagy.
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- Nature Immunology, 2014, v. 15, n. 2, p. 142, doi. 10.1038/ni.2817
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- Article
Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling.
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- Nature Immunology, 2014, v. 15, n. 2, p. 186, doi. 10.1038/ni.2772
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- Article
RKIP expression of liver and kidney after arsenic exposure.
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- Environmental Toxicology, 2017, v. 32, n. 3, p. 1079, doi. 10.1002/tox.22291
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- Article
Systemic network analysis identifies XIAP and IκBα as potential drug targets in TRAIL resistant BRAF mutated melanoma.
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- NPJ Systems Biology & Applications, 2018, v. 4, n. 1, p. N.PAG, doi. 10.1038/s41540-018-0075-y
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- Article
Large-scale computational drug repositioning to find treatments for rare diseases.
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- NPJ Systems Biology & Applications, 2018, v. 4, n. 1, p. N.PAG, doi. 10.1038/s41540-018-0050-7
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- Article
Analysis of the pharmacoeconomic effectiveness of the tyrosine kinase inhibitors therapy in patients with chronic myeloid leukemia in a Single Hematology Center in Plovdiv, Bulgaria.
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- Pharmacia (0428-0296), 2024, v. 71, n. 1, p. 1, doi. 10.3897/pharmacia.71.e126016
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- Article
Application of biological medicinal products and tyrosine kinase inhibitors in rheumatoid arthritis and COVID-19: A systematic review of scientific literature.
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- Pharmacia (0428-0296), 2024, v. 71, n. 1, p. 1, doi. 10.3897/pharmacia.71.e124471
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- Article
Analysis of the pharmacotherapeutic effectiveness of the tyrosine kinase inhibitors therapy in patients with Chronic Myeloid Leukemia in a single hematology center in Plovdiv, Bulgaria.
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- Pharmacia (0428-0296), 2023, v. 70, n. 4, p. 1355, doi. 10.3897/pharmacia.70.e111923
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- Article
Early-stage breast cancer: Update on management.
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- Medicine Today, 2024, v. 25, n. 3, p. 45
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- Article
Bacterial Histidine Kinase and the Development of Its Inhibitors in the 21st Century.
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- Antibiotics (2079-6382), 2024, v. 13, n. 7, p. 576, doi. 10.3390/antibiotics13070576
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- Article
Utilization of Existing Human Kinase Inhibitors as Scaffolds in the Development of New Antimicrobials.
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- Antibiotics (2079-6382), 2023, v. 12, n. 9, p. 1418, doi. 10.3390/antibiotics12091418
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- Article
Quercetin Is a Novel Inhibitor of the Choline Kinase of Streptococcus pneumoniae.
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- Antibiotics (2079-6382), 2022, v. 11, n. 9, p. 1272, doi. 10.3390/antibiotics11091272
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- Article
Computational Design of Inhibitors Targeting the Catalytic β Subunit of Escherichia coli F O F 1 -ATP Synthase.
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- Antibiotics (2079-6382), 2022, v. 11, n. 5, p. 557, doi. 10.3390/antibiotics11050557
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- Article