Works matching DE "CHECKPOINT kinase 1"
Results: 147
Relative free-energy calculations for scaffold hopping-type transformations with an automated RE-EDS sampling procedure.
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- Journal of Computer-Aided Molecular Design, 2022, v. 36, n. 2, p. 117, doi. 10.1007/s10822-021-00436-z
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Molecular insights into the microtubules depolymerizing activity of the IL-8 receptor B antagonist SB225002.
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- European Review for Medical & Pharmacological Sciences, 2022, v. 26, n. 10, p. 3726
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- Article
Correction: Hsiao et al. Claspin-Dependent and -Independent Chk1 Activation by a Panel of Biological Stresses. Biomolecules 2023, 13 , 125.
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- 2023
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- Correction Notice
Claspin-Dependent and -Independent Chk1 Activation by a Panel of Biological Stresses.
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- Biomolecules (2218-273X), 2023, v. 13, n. 1, p. 125, doi. 10.3390/biom13010125
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- Article
Lipid raft‐disrupting miltefosine preferentially induces the death of colorectal cancer stem‐like cells.
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- Clinical & Translational Medicine, 2021, v. 11, n. 11, p. 1, doi. 10.1002/ctm2.552
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Combined inhibition of Wee1 and Chk1 as a therapeutic strategy in multiple myeloma.
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- Frontiers in Oncology, 2023, p. 1, doi. 10.3389/fonc.2023.1271847
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Identification of hub genes and their correlation with infiltration of immune cells in MYCN positive neuroblastoma based on WGCNA and LASSO algorithm.
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- Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.1016683
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- Article
Enhancing the Efficacy of Radiotherapy in Gastric Adenocarcinoma Cells by Gut Microbiota Metabolites: Implications for Urolithin Combination Therapy.
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- Natural Product Communications, 2024, v. 19, n. 12, p. 1, doi. 10.1177/1934578X241310020
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Bioinformatic Analysis of Ping-Wei-San Decoction for Pulmonary Malignancy Based on UPLC-QE-Orbitrap-MS Detection.
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- Natural Product Communications, 2024, v. 19, n. 5, p. 1, doi. 10.1177/1934578X241249089
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- Article
Checkpoint kinase 1 inhibitor + low‐dose hydroxyurea efficiently kills BRAF inhibitor‐ and immune checkpoint inhibitor‐resistant melanomas.
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- Pigment Cell & Melanoma Research, 2024, v. 37, n. 1, p. 45, doi. 10.1111/pcmr.13120
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- Article
The KRAS, ATR and CHEK1 expression levels in endometrial cancer are the risk factors predicting recurrence.
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- PLoS ONE, 2024, v. 19, n. 4, p. 1, doi. 10.1371/journal.pone.0302075
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Correction: ERK1/2 Signaling Plays an Important Role in Topoisomerase II Poison-Induced G2/M Checkpoint Activation.
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- 2023
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- Correction Notice
MK-8776 and Olaparib Combination Acts Synergistically in Hepatocellular Carcinoma Cells, Demonstrating Lack of Adverse Effects on Liver Tissues in Ovarian Cancer PDX Model.
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- International Journal of Molecular Sciences, 2025, v. 26, n. 2, p. 834, doi. 10.3390/ijms26020834
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Targeting Metabolic and Epigenetic Vulnerabilities in Glioblastoma with SN-38 and Rabusertib Combination Therapy.
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- International Journal of Molecular Sciences, 2025, v. 26, n. 2, p. 474, doi. 10.3390/ijms26020474
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- Article
Correlation between Molecular Docking and the Stabilizing Interaction of HOMO-LUMO: Spirostans in CHK1 and CHK2, an In Silico Cancer Approach.
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- International Journal of Molecular Sciences, 2024, v. 25, n. 16, p. 8588, doi. 10.3390/ijms25168588
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Novel Amidine Derivative K1586 Sensitizes Colorectal Cancer Cells to Ionizing Radiation by Inducing Chk1 Instability.
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- International Journal of Molecular Sciences, 2024, v. 25, n. 8, p. 4396, doi. 10.3390/ijms25084396
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Key Proteins of Replication Stress Response and Cell Cycle Control as Cancer Therapy Targets.
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- International Journal of Molecular Sciences, 2024, v. 25, n. 2, p. 1263, doi. 10.3390/ijms25021263
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Identification of CDK1, PBK, and CHEK1 as an Oncogenic Signature in Glioblastoma: A Bioinformatics Approach to Repurpose Dapagliflozin as a Therapeutic Agent.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 22, p. 16396, doi. 10.3390/ijms242216396
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A Multimodel Study of the Role of Novel PKC Isoforms in the DNA Integrity Checkpoint.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 21, p. 15796, doi. 10.3390/ijms242115796
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Involvement of the p38/MK2 Pathway in MCLR Hepatotoxicity Revealed through MAPK Pharmacological Inhibition and Phosphoproteomics in HepaRG Cells.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 13, p. 11168, doi. 10.3390/ijms241311168
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Checkpoint Kinase 1 Is a Key Signal Transducer of DNA Damage in the Early Mammalian Cleavage Embryo.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 7, p. 6778, doi. 10.3390/ijms24076778
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Plumbagin Exhibits Genotoxicity and Induces G2/M Cell Cycle Arrest via ROS-Mediated Oxidative Stress and Activation of ATM-p53 Signaling Pathway in Hepatocellular Cells.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 7, p. 6279, doi. 10.3390/ijms24076279
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- Article
PKR-Mediated Phosphorylation of eIF2a and CHK1 Is Associated with Doxorubicin-Mediated Apoptosis in HCC1143 Triple-Negative Breast Cancer Cells.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 24, p. 15872, doi. 10.3390/ijms232415872
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- Article
Thiosemicarbazones Can Act Synergistically with Anthracyclines to Downregulate CHEK1 Expression and Induce DNA Damage in Cell Lines Derived from Pediatric Solid Tumors.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 15, p. 8549, doi. 10.3390/ijms23158549
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Mechanism-Based Sonodynamic–Chemo Combinations against Triple-Negative Breast Cancer.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 14, p. 7981, doi. 10.3390/ijms23147981
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- Article
Enhanced Anti-Cancer Effects of Conditioned Medium from Hypoxic Human Adult Dermal Fibroblasts on Cervical Cancer Cells.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 9, p. 5134, doi. 10.3390/ijms23095134
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- Article
VPA and TSA Interrupt the Interplay between mutp53 and HSP70, Leading to CHK1 and RAD51 Down-Regulation and Sensitizing Pancreatic Cancer Cells to AZD2461 PARP Inhibitor.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 4, p. 2268, doi. 10.3390/ijms23042268
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MHY2245, a Sirtuin Inhibitor, Induces Cell Cycle Arrest and Apoptosis in HCT116 Human Colorectal Cancer Cells.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 3, p. 1590, doi. 10.3390/ijms23031590
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Checkpoint Kinase 1 (CHK1) Inhibition Enhances the Sensitivity of Triple-Negative Breast Cancer Cells to Proton Irradiation via Rad51 Downregulation.
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- International Journal of Molecular Sciences, 2020, v. 21, n. 8, p. 2691, doi. 10.3390/ijms21082691
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- Article
Gemcitabine and ATR inhibitors synergize to kill PDAC cells by blocking DNA damage response.
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- Molecular Systems Biology, 2025, v. 21, n. 3, p. 231, doi. 10.1038/s44320-025-00085-6
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Comparative effects of arsenic trioxide and chemotherapy on Chk1 and CDC25 gene expression in gastric cancer cells AGS and MKN45: a potential therapeutic strategy.
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- Molecular Biology Reports, 2025, v. 52, n. 1, p. 1, doi. 10.1007/s11033-025-10313-9
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- Article
Immune modulating activity of the CHK1 inhibitor prexasertib and anti-PD-L1 antibody LY3300054 in patients with high-grade serous ovarian cancer and other solid tumors.
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- Cancer Immunology, Immunotherapy, 2021, v. 70, n. 10, p. 2991, doi. 10.1007/s00262-021-02910-x
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The role of USP51 in attenuating chemosensitivity of lung cancer cells to cisplatin by regulating DNA damage response.
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- Biotechnology & Applied Biochemistry, 2023, v. 70, n. 2, p. 634, doi. 10.1002/bab.2386
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A cellular senescence-related signature for predicting prognosis, immunotherapy response, and candidate drugs in patients treated with transarterial chemoembolization (TACE).
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- Discover Oncology, 2024, v. 15, n. 1, p. 1, doi. 10.1007/s12672-024-01116-8
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- Article
STAU2 protein level is controlled by caspases and the CHK1 pathway and regulates cell cycle progression in the non-transformed hTERT-RPE1 cells.
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- BMC Molecular & Cell Biology, 2021, v. 22, n. 1, p. 1, doi. 10.1186/s12860-021-00352-y
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- Article
Overexpression of CHK1 and CHK2 in pediatric patients of B -acute lymphoblastic leukemia.
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- Iranian Journal of Pediatric Hematology & Oncology, 2023, v. 13, n. 4, p. 233, doi. 10.18502/ijpho.v13i4.13769
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- Article
Dynamic structural remodeling of LINC01956 enhances temozolomide resistance in MGMT-methylated glioblastoma.
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- Science Translational Medicine, 2024, v. 16, n. 767, p. 1, doi. 10.1126/scitranslmed.ado1573
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- Article
BLM overexpression as a predictive biomarker for CHK1 inhibitor response in PARP inhibitor–resistant BRCA-mutant ovarian cancer.
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- Science Translational Medicine, 2023, v. 15, n. 701, p. 1, doi. 10.1126/scitranslmed.add7872
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- Article
Replication stress response defects are associated with response to immune checkpoint blockade in nonhypermutated cancers.
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- Science Translational Medicine, 2021, v. 13, n. 617, p. 1, doi. 10.1126/scitranslmed.abe6201
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- Article
Ubiquitination of the DNA-damage checkpoint kinase CHK1 by TRAF4 is required for CHK1 activation.
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- Journal of Hematology & Oncology, 2020, v. 13, n. 1, p. 1, doi. 10.1186/s13045-020-00869-3
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- Article
CHEK1 and circCHEK1_246aa evoke chromosomal instability and induce bone lesion formation in multiple myeloma.
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- Molecular Cancer, 2021, v. 20, n. 1, p. 1, doi. 10.1186/s12943-021-01380-0
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- Article
An effective kinase inhibition strategy for metastatic recurrent childhood medulloblastoma.
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- Journal of Neuro-Oncology, 2023, v. 163, n. 3, p. 635, doi. 10.1007/s11060-023-04372-w
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- Article
Relationship between DNA mismatch repair and CRISPR/Cas9-mediated knock-in in the bovine β-casein gene locus.
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- Animal Bioscience, 2022, v. 35, n. 1, p. 126, doi. 10.5713/ab.21.0117
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- Article
Vitamin-Containing Antioxidant Formulation Reduces Carcinogen-Induced DNA Damage through ATR/Chk1 Signaling in Bronchial Epithelial Cells In Vitro.
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- Biomedicines, 2021, v. 9, n. 11, p. 1665, doi. 10.3390/biomedicines9111665
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- Article
Impact of Chk1 dosage on somatic hypermutation in vivo.
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- Immunology & Cell Biology, 2021, v. 99, n. 8, p. 879, doi. 10.1111/imcb.12480
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- Article
AZD6738 Inhibits fibrotic response of conjunctival fibroblasts by regulating checkpoint kinase 1/P53 and PI3K/AKT pathways.
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- Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.990401
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- Article
Integrative Bioinformatics Analysis Reveals CHEK1 and UBE2C as Luminal A Breast Cancer Subtype Biomarkers.
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- Frontiers in Genetics, 2022, v. 13, p. 1, doi. 10.3389/fgene.2022.944259
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- Article
Combination Therapies with Kinase Inhibitors for Acute Myeloid Leukemia Treatment.
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- Hematology Reports, 2023, v. 15, n. 2, p. 331, doi. 10.3390/hematolrep15020035
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- Article
Brooding Temperature Alters Yolk Sac Absorption and Affected Ovarian Development in Goslings.
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- Animals (2076-2615), 2022, v. 12, n. 12, p. 1513, doi. 10.3390/ani12121513
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- Article
Novel therapeutic approach for uterine leiomyosarcoma based on transcriptome analysis.
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- Journal of Gynecologic Oncology, 2022, v. 33, p. S1, doi. 10.3802/jgo.2022.33.S1
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- Article