Rare earth-based MOF@mesoporous silica nanoplatform for long-term and luminescence trackable chemotherapy.

Wang, Lu-Min; Liu, Wen-Yan; Hu, Ming-Liang; Yao, Jia-Sai; Wang, Ping; Liu, Jia-Hao; He, Miao; Gao, Yi; Li, Zhen-Xing

Developing the multifunctional nanocarriers for long-term drug release and luminescence traceability is a challenging assignment. In this task, we designed a novel nanoplatform for long-term and luminescence trackable chemotherapy, which is prepared via a hollow ZIF-8 (where ZIF is zeolitic imidazolate frameworks) coated by the Eu3 -doped mesoporous silica (ZIF-8@mesoporous silica). The hollow ZIF-8 is used as a drug library for loading the anticancer drug, and the pH-sensitive properties of ZIF-8 can targeted-release drugs in the tumor and cut down the poisonousness of drugs to normal cells. The shell layer of mesoporous silica can achieve the long-term drug release, which solves the problem of short drug circulation time in the body, reduces the drug administration frequency, and improves the therapeutic effect. Notably, the ZIF-8@mesoporous doxorubicin (DOX) is injected only once during the 14-day chemotherapy. In addition, Eu3 - doped in mesoporous silica ensures luminescence tracking and detection of drug pathways in living cells. Hence, this nanoplatform provides a whole new strategy for the long-term treatment of tumors.

Rare Metals, 2022, Vol 41, Issue 8, p2701

1001-0521

Academic Journal

10.1007/s12598-022-01978-3