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- Title
An aptamer-driven DNA nanodevice for improved delivery of synthetic immunostimulants.
- Authors
Lu, Dejie; Di, Zhenghan; Li, Lele; Zhao, Jian; Zheng, Li
- Abstract
Efficient delivery of therapeutics to immune cells remains a formidable challenge for cancer immunotherapy. In this work, we demonstrate that an aptamer-driven DNA nanodevice, constructed through linkage of a synthetic immunostimulant (Toll-like receptor 9 agonist: CpG motif) to an aptamer, could significantly enhance the immunostimulatory activity by facilitating the uptake and retention of therapeutics in macrophages. Systemic administration of the DNA nanodevice results in efficient tumor growth inhibition in both breast cancer and melanoma mouse models. Our studies suggest that the DNA nanodevice leads to reeducation of tumor-associated macrophages and ultimately to reversing the tumor immune microenvironment. The strategy for aptamer-mediated and vehicle-free delivery of immunostimulatory oligonucleotides provides a potential platform for cancer immunotherapy.
- Subjects
TOLL-like receptor agonists; CANCER treatment; TUMOR growth; TUMOR microenvironment; BREAST cancer; APTAMERS
- Publication
Nano Research, 2024, Vol 17, Issue 10, p9078
- ISSN
1998-0124
- Publication type
Academic Journal
- DOI
10.1007/s12274-024-6632-3