Results
Title

The Molecular Mechanism of Aluminum Phosphide poisoning in Cardiovascular Disease: Pathophysiology and Diagnostic Approach.

Authors

Hosseini, Seyed Farzad; Forouzesh, Mehdi; Maleknia, Mohsen; Valiyari, Samira; Maniati, Mahmood; Samimi, Azin

Abstract

Nowadays, poisoning with metal phosphides, especially aluminum phosphide (ALP), is one of the main health threats in human societies. Patients suffer from significant complications due to this type of poisoning, and the heart is one of the main organs targeted by ALP. Therefore, in this study, we discussed the effect of phosphine on cardiac function. This study is based on data obtained from PubMed, between 2002 and 2020. The key keywords included "Aluminum phosphide," "Oxidative Stress," "Mitochondria," "Cardiovascular disease," and "Treatment." The results showed that ALP produced reactive oxygen species (ROS) due to mitochondrial dysfunction. ROS production leads to red blood cell hemolysis, decreased ATP production, and induction of apoptosis in cardiomyocytes, which eventually results in cardiovascular disease. Since ALP has the most significant effect on cardiomyocytes, the use of appropriate treatment strategies to restore cell function can increase patients' survival.

Subjects

ALUMINUM phosphide; REACTIVE oxygen species; CARDIOVASCULAR diseases; POISONING; PATHOLOGICAL physiology; SELF-poisoning

Publication

Cardiovascular Toxicology, 2020, Vol 20, Issue 5, p454

ISSN

1530-7905

Publication type

Academic Journal

DOI

10.1007/s12012-020-09592-4