Effect of Prepubertal Exposure to CdCl2 on the Liver, Hematological, and Biochemical Parameters in Female Rats; an Experimental Study.

Saedi, Saman; Jafarzadeh Shirazi, Mohammad Reza; Totonchi, Mehdi; Zamiri, Mohammad Javad; Derakhshanfar, Amin

The examination chemical factors including industrial toxins and heavy metals seem to be crucial during the prepubertal period. In order to investigate the effects of prepubertal exposure to toxic doses of Cd on liver, hematological, and biochemical parameters in the serum, 16 female rats weaned on postnatal day (PND) 21 were randomly divided into four groups with four rats in each (n = 4). The treatments were as follows: control (0.5 mL distilled water), 25, 50, and 75 mg/kg/day received cadmium chloride (CdCl2). The CdCl2 were administered orally from PND 21 days until observed first vaginal opening (VO). The result showed that the treatment of 75 mg/kg CdCl2 dramatically increased the serum level of LDL (P 3/μL) showed significant difference (P 3/μL). Histopathological exams showed nodular accumulation of lymphocytes in the liver (lymphocytic hepatitis) of rats, treated with 75 mg/kg CdCl2. These results showed that CdCl2 could cause change in serum lipidome and hematological parameters. What is more, exposure to Cd triggers liver injury and cardiovascular disease during the prepubertal period.

RATS; LIVER; CADMIUM chloride; DISTILLED water; HEAVY metals; BLOOD cell count

Biological Trace Element Research, 2020, Vol 194, Issue 2, p472

0163-4984

Academic Journal

10.1007/s12011-019-01800-9