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- Title
Fucoidans from Brown Seaweeds Sargassum hornery, Eclonia cava, Costaria costata: Structural Characteristics and Anticancer Activity.
- Authors
Ermakova, Svetlana; Sokolova, Roza; Sang-Min Kim; Byung-Hun Um; Isakov, Vladimir; Zvyagintseva, Tatyana
- Abstract
Fucoidans were isolated by water extraction and ion-exchange chromatography from brown algae Eclonia cava, Sargassum hornery, and Costaria costata collected near of Korean coasts. The structures of fucoidans were investigated. Fucoidan from E. cava was mixture of sulfated rhamnogalactofucan and galactofucan. Fucoidan from C. costata was a sulfated galactofucan. Fucoidan isolated from S. hornery was separated into three fractions: a homofucan sulfate, a homofucan but without sulfate groups, and a sulfated rhamnofucan. The results clearly showed that fucoidans play an inhibitory role in colony formation in human melanoma and colon cancer cells and may be effective antitumor agents.
- Subjects
MARINE algae; SARGASSUM; POLYSACCHARIDES; SULFATES; ION exchange (Chemistry)
- Publication
Applied Biochemistry & Biotechnology, 2011, Vol 164, Issue 6, p841
- ISSN
0273-2289
- Publication type
Academic Journal
- DOI
10.1007/s12010-011-9178-2