Title: Fucoidans from Brown Seaweeds Sargassum hornery, Eclonia cava, Costaria costata: Structural Characteristics and Anticancer Activity.
Authors: Ermakova, Svetlana; Sokolova, Roza; Sang-Min Kim; Byung-Hun Um; Isakov, Vladimir; Zvyagintseva, Tatyana
Abstract: Fucoidans were isolated by water extraction and ion-exchange chromatography from brown algae Eclonia cava, Sargassum hornery, and Costaria costata collected near of Korean coasts. The structures of fucoidans were investigated. Fucoidan from E. cava was mixture of sulfated rhamnogalactofucan and galactofucan. Fucoidan from C. costata was a sulfated galactofucan. Fucoidan isolated from S. hornery was separated into three fractions: a homofucan sulfate, a homofucan but without sulfate groups, and a sulfated rhamnofucan. The results clearly showed that fucoidans play an inhibitory role in colony formation in human melanoma and colon cancer cells and may be effective antitumor agents.
Subjects: MARINE algae; SARGASSUM; POLYSACCHARIDES; SULFATES; ION exchange (Chemistry)
Publication: Applied Biochemistry & Biotechnology, 2011, Vol 164, Issue 6, p841
ISSN: 0273-2289
Publication type: Academic Journal
DOI: 10.1007/s12010-011-9178-2

Fucoidans from Brown Seaweeds Sargassum hornery, Eclonia cava, Costaria costata: Structural Characteristics and Anticancer Activity.

Ermakova, Svetlana; Sokolova, Roza; Sang-Min Kim; Byung-Hun Um; Isakov, Vladimir; Zvyagintseva, Tatyana