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- Title
Inhibition of Pro-inflammatory Secreted Phospholipase A2 by Extracts from Cynara cardunculus L.
- Authors
Kammoun, Maher; Koubaa, Imed; Ali, Yassine Ben; Jarraya, Raoudha; Gargouri, Youssef; Damak, Mohamed; Bezzine, Sofiane
- Abstract
The aim of the present work was to evaluate the anti-inflammatory properties of Cynara cardunculus L. (Asteraceae) during its growth using various solvents such as n-hexane, dichloromethane, acetone, and methanol for air-dried leaves and stems. The anti-inflammatory activities of crude extracts were evaluated by measuring the inhibition potency of mammalian non-pancreatic phospholipases A2 (hG-IIA). The methanol and acetone extracts of leaves harvested in February exhibit potent inhibition of hG-IIA (IC50 = 50 and 70 µg/ml, respectively). However, the acetone extract of stems harvested in December inhibits the hG-IIA with a lower IC50 around 130 µg/ml. Fractionation on silica gel and hydrophobic gel of the methanol extract of leaves harvested in February increases the inhibitory effect, and the IC50 reached 10 µg/ml.
- Subjects
PHOSPHOLIPASE A2; PLANT extracts; ENZYMES; ANTI-inflammatory agents; PHOSPHOLIPASES
- Publication
Applied Biochemistry & Biotechnology, 2010, Vol 162, Issue 3, p662
- ISSN
0273-2289
- Publication type
Academic Journal
- DOI
10.1007/s12010-009-8849-8