The Effect of Bariatric Surgery on Irisin Level: a Systematic Review and Meta-analysis.

Bidares, Matin; Safari-kish, Borna; Abedi, Motahare; Malekzadeh-shoushtari, Hesam; Jasemnezhad, Malek; Azarbayejani, Niloufar; Aziz, Mahsa; Jahromi, Sayna Pejouhesh; Fouladi, Samar; Azizi-Soleiman, Fatemeh

This systematic analysis and meta-analysis aimed to assess changes in the plasma levels of irisin after bariatric surgery. Search strategy, study screening, and data gathering were all conducted using a checklist and the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Two researchers independently extracted the data, and a third person was included to resolve disagreements. The results illustrated no statistical difference between before and after surgery irisin plasma levels (P = 0.216, 95% CI = −1.812–0.410, SMD = −0.701, I-squared = 94.9%). BMI exhibited a meaningful decline after surgery compared to preoperative values (SMD = −3.09, 95% CI = −4.59–−1.59, I-squared = 95.5%, P<0.05). According to our analysis, it can be concluded that irisin plasma levels are not significantly influenced by bariatric surgery.

BARIATRIC surgery; IRISIN; RESEARCH personnel

Obesity Surgery, 2023, Vol 33, Issue 10, p3256

0960-8923

Academic Journal

10.1007/s11695-023-06764-3