Works matching DE "METHYLTHIOADENOSINE"

Results: 33

Leishmania infantum 5'-Methylthioadenosine Phosphorylase presents relevant structural divergence to constitute a potential drug target.

Published in:

BMC Structural Biology, 2017, v. 17, p. 1, doi. 10.1186/s12900-017-0079-7

By:

Abid, Hela;
Harigua-Souiai, Emna;
Mejri, Thouraya;
Barhoumi, Mourad;
Guizani, Ikram

Publication type:

Article

Transition state analogue of MTAP extends lifespan of APCMin/+ mice.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-87734-6

By:

Firestone, Ross S.;
Feng, Mu;
Basu, Indranil;
Peregrina, Karina;
Augenlicht, Leonard H.;
Schramm, Vern L.

Publication type:

Article

Molecular dynamics study of the effect of active site protonation on Helicobacter pylori 5′-methylthioadenosine/ S-adenosylhomocysteine nucleosidase.

Published in:

European Biophysics Journal, 2015, v. 44, n. 8, p. 685, doi. 10.1007/s00249-015-1067-0

By:

Tekpinar, Mustafa;
Yildirim, Ahmet;
Wassenaar, Tsjerk

Publication type:

Article

Effects of S-adenosylmethionine and methylthioadenosine on inflammation-induced colon cancer in mice.

Published in:

Carcinogenesis, 2012, v. 33, n. 2, p. 427, doi. 10.1093/carcin/bgr295

By:

Li, Tony W.H.;
Yang, Heping;
Peng, Hui;
Xia, Meng;
Mato, José M.;
Lu, Shelly C.

Publication type:

Article

Characterization of the Methylthioadenosine Phosphorylase Polymorphism rs7023954 - Incidence and Effects on Enzymatic Function in Malignant Melanoma.

Published in:

PLoS ONE, 2016, v. 11, n. 8, p. 1, doi. 10.1371/journal.pone.0160348

By:

Limm, Katharina;
Dettmer, Katja;
Reinders, Jörg;
Oefner, Peter J.;
Bosserhoff, Anja-Katrin

Publication type:

Article

Eculizumab for the treatment of pregnancy-related atypical hemolytic uremic syndrome.

Published in:

2014

By:

Cañigral, Carolina;
Moscardó, Federico;
Castro, Cristina;
Pajares, Azucena;
Lancharro, Aima;
Solves, Pilar;
Rubia, Javier;
Carpio, Nelly;
Sanz, Miguel

Publication type:

Letter

Octreotide prevents liver failure through upregulating 5′-methylthioadenosine in extended hepatectomized rats.

Published in:

Liver International, 2016, v. 36, n. 2, p. 212, doi. 10.1111/liv.12863

By:

Du, Zhenggui;
Zhou, Yongjie;
Lu, Xufeng;
Li, Lei;
Lu, Changli;
Li, Li;
Li, Bo;
Bu, Hong;
Yang, Jiayin;
Shi, Yujun

Publication type:

Article

Synthesis of new naphthostyryl derivatives via nucleophilic substitution of methylthio group with C-nucleophiles. Molecular and crystal structure of ( Z)-2-{benzo[ cd]indol-2(1 H)-ylidene}-2-(4-phenythiazol-2-yl)acetonitrile.

Published in:

Russian Journal of General Chemistry, 2014, v. 84, n. 2, p. 259, doi. 10.1134/S1070363214020169

By:

Dyachenko, V.;
Kashner, A.;
Samusenko, Yu.

Publication type:

Article

Metabolic characteristics and importance of the universal methionine salvage pathway recycling methionine from 5′-methylthioadenosine.

Published in:

IUBMB Life, 2009, v. 61, n. 12, p. 1132, doi. 10.1002/iub.278

By:

Albers, Eva

Publication type:

Article

Methylthioadenosine phosphorylase (MTAP)-deficient T-cell ALL xenografts are sensitive to pralatrexate and 6-thioguanine alone and in combination.

Published in:

Cancer Chemotherapy & Pharmacology, 2015, v. 75, n. 6, p. 1247, doi. 10.1007/s00280-015-2747-2

By:

Tedeschi, Philip;
Kathari, Yamini;
Johnson-Farley, Nadine;
Bertino, Joseph

Publication type:

Article

Structures of lipoyl synthase reveal a compact active site for controlling sequential sulfur insertion reactions.

Published in:

Biochemical Journal, 2014, v. 464, n. 1, p. 123, doi. 10.1042/BJ20140895

By:

Harmer, Jenny E.;
Hiscox, Martyn J.;
Dinis, Pedro C.;
Fox, Stephen J.;
Iliopoulos, Andreas;
Hussey, James E.;
Sandy, James;
Van Beek, Florian T.;
Essex, Jonathan W.;
Roach, Peter L.

Publication type:

Article

Metabolomic and transcriptomic profiling reveals the alteration of energy metabolism in oyster larvae during initial shell formation and under experimental ocean acidification.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-62963-3

By:

Liu, Zhaoqun;
Zhang, Yukun;
Zhou, Zhi;
Zong, Yanan;
Zheng, Yan;
Liu, Chang;
Kong, Ning;
Gao, Qiang;
Wang, Lingling;
Song, Linsheng

Publication type:

Article

DRUG REPURPOSING TOWARDS THE IDENTIFICATION OF NOVEL ANTI-LEISHMANIA MOLECULES TARGETING THE METHYLTHIOADENOSINE PHOSPHORYLASE.

Published in:

Archives de l'Institut Pasteur de Tunis, 2020, v. 97, n. 1-4, p. 31

By:

MOUSSA, Z.;
HARIGUA-SOUIAI, E.;
BARHOUMI, M.;
GUIZANI, I.

Publication type:

Article

Simple and efficient synthesis of new N(3)-, O- and S-substituted 2-methylthio-6-phenylpyrimidin- 4(3H)-one based derivatives.

Published in:

Chemija, 2016, v. 27, n. 2, p. 128, doi. 10.6001/chemija.2016.27.2.6

By:

Burbulienė, Milda Malvina;
Dargytė, Julita;
Maldutytė, Eglė;
Vainilavičius, Povilas

Publication type:

Article

Methylthioadenosine phosphorylase inactivation depends on gene deletion in laryngeal squamous cell carcinoma.

Published in:

Histopathology, 2012, v. 61, n. 6, p. 1082, doi. 10.1111/j.1365-2559.2012.04353.x

By:

Conde, Laura;
Vilaseca, Isabel;
Alós, Llucia;
Bernal-Sprekelsen, Manuel;
Cardesa, Antonio;
Nadal, Alfons

Publication type:

Article

Identification of a 2-cell stage specific inhibitor of the cleavage of preimplantation mouse embryos synthesized by rat hepatoma cells as 5′-deoxy-5′-methylthioadenosine.

Published in:

Zygote, 2011, v. 19, n. 2, p. 117, doi. 10.1017/S0967199410000158

By:

Kobayashi, Masayuki;
Saito, Koichi;
Tamogami, Shigeru;
Takashima, Junko;
Kasuga, Kano;
Kojima, Ikuo

Publication type:

Article

Phloem-Specific Methionine Recycling Fuels Polyamine Biosynthesis in a Sulfur-DependentManner and Promotes Flower and Seed Development.

Published in:

Plant Physiology, 2016, v. 170, n. 2, p. 790, doi. 10.1104/pp.15.00786

By:

Zierer, Wolfgang;
Hajirezaei, Mohammad R.;
Eggert, Kai;
Sauer, Norbert;
von Wirén, Nicolaus;
Pommerrenig, Benjamin

Publication type:

Article

Recycling of Methylthioadenosine Is Essential for Normal Vascular Development and Reproduction in Arabidopsis.

Published in:

Plant Physiology, 2012, v. 158, n. 4, p. 1728, doi. 10.1104/pp.111.191072

By:

Waduwara-Jayabahu, Ishari;
Oppermann, Yasmin;
Wirtz, Markus;
Hull, Zachary T.;
Schoor, Sarah;
Plotnikov, Alexander N.;
Hell, Rüdiger;
Sauter, Margret;
Moffatt, Barbara A.

Publication type:

Article

Crystal Structure of Schistosoma mansoni Adenosine Phosphorylase/5’-Methylthioadenosine Phosphorylase and Its Importance on Adenosine Salvage Pathway.

Published in:

PLoS Neglected Tropical Diseases, 2016, v. 10, n. 12, p. 1, doi. 10.1371/journal.pntd.0005178

By:

Torini, Juliana Roberta;
Brandão-Neto, José;
DeMarco, Ricardo;
Pereira, Humberto D'Muniz

Publication type:

Article

Methylthioadenosine Reprograms Macrophage Activation through Adenosine Receptor Stimulation.

Published in:

PLoS ONE, 2014, v. 9, n. 8, p. 1, doi. 10.1371/journal.pone.0104210

By:

Keyel, Peter A.;
Romero, Matthew;
Wu, Wenbo;
Kwak, Daniel H.;
Zhu, Qin;
Liu, Xinyu;
Salter, Russell D.

Publication type:

Article

Differential Neuroprotective Effects of 5′-Deoxy-5′-Methylthioadenosine.

Published in:

PLoS ONE, 2014, v. 9, n. 3, p. 1, doi. 10.1371/journal.pone.0090671

By:

Moreno, Beatriz;
Lopez, Iciar;
Fernández-Díez, Begoña;
Gottlieb, Miroslav;
Matute, Carlos;
Sánchez-Gómez, María Victoria;
Domercq, María;
Giralt, Albert;
Alberch, Jordi;
Collon, Kevin W.;
Zhang, Helen;
Parent, Jack M.;
Teixido, Meritxell;
Giralt, Ernest;
Ceña, Valentín;
Posadas, Inmaculada;
Martínez-Pinilla, Eva;
Villoslada, Pablo;
Franco, Rafael

Publication type:

Article

Expression and Function of Methylthioadenosine Phosphorylase in Chronic Liver Disease.

Published in:

PLoS ONE, 2013, v. 8, n. 12, p. 1, doi. 10.1371/journal.pone.0080703

By:

Czech, Barbara;
Dettmer, Katja;
Valletta, Daniela;
Saugspier, Michael;
Koch, Andreas;
Stevens, Axel P.;
Thasler, Wolfgang E.;
Müller, Martina;
Oefner, Peter J.;
Bosserhoff, Anja-Katrin;
Hellerbrand, Claus

Publication type:

Article

Germline Mutations in Mtap Cooperate with Myc to Accelerate Tumorigenesis in Mice.

Published in:

PLoS ONE, 2013, v. 8, n. 6, p. 1, doi. 10.1371/journal.pone.0067635

By:

Kadariya, Yuwaraj;
Tang, Baiqing;
Wang, Liqun;
Al-Saleem, Tahseen;
Hayakawa, Kyoko;
Slifker, Michael J.;
Kruger, Warren D.

Publication type:

Article

A Study on the Interaction of Rhodamine B with Methylthioadenosine Phosphorylase Protein Sourced from an Antarctic Soil Metagenomic Library.

Published in:

PLoS ONE, 2013, v. 8, n. 1, p. 1, doi. 10.1371/journal.pone.0055697

By:

Bartasun, Paulina;
Cieśliński, Hubert;
Bujacz, Anna;
Wierzbicka-Woś, Anna;
Kur, Józef

Publication type:

Article

Multilevel pharmacokinetics-driven modeling of metabolomics data.

Published in:

Metabolomics, 2017, v. 13, n. 3, p. 1, doi. 10.1007/s11306-017-1164-4

By:

Daghir-Wojtkowiak, Emilia;
Wiczling, Paweł;
Waszczuk-Jankowska, Małgorzata;
Kaliszan, Roman;
Markuszewski, Michał

Publication type:

Article

Integration of untargeted metabolomics with transcriptomics reveals active metabolic pathways.

Published in:

Metabolomics, 2015, v. 11, n. 3, p. 503, doi. 10.1007/s11306-014-0713-3

By:

Cho, Kyuil;
Evans, Bradley;
Wood, B.;
Kumar, Ritesh;
Erb, Tobias;
Warlick, Benjamin;
Gerlt, John;
Sweedler, Jonathan

Publication type:

Article

Crystallization and preliminary X-ray diffraction analysis of the interaction of Aeromonas hydrophila MtaN-1 with S-adenosylhomocysteine.

Published in:

Acta Crystallographica: Section F, Structural Biology Communications, 2015, v. 71, n. 4, p. 393, doi. 10.1107/S2053230X15003647

By:

Xu, Yongbin;
Quan, Chun-Shan;
Jin, Xiaoling;
Jin, Xuanzhen;
Zhao, Jing;
Jin, Liming;
Kim, Jin-Sik;
Guo, Jianyun;
Fan, Shengdi;
Ha, Nam-Chul

Publication type:

Article

Characterization of methylthioadenosin phosphorylase (MTAP) expression in colorectal cancer.

Published in:

Artificial Cells, Nanomedicine & Biotechnology, 2018, v. 46, n. 8, p. 2082, doi. 10.1080/21691401.2017.1408122

By:

Zhong, Yanmei;
Lu, Keliang;
Zhu, Suhua;
Li, Wentong;
Sun, Shanming

Publication type:

Article

Inhibition of 5’-methylthioadenosine metabolism in the Yang cycle alters polyamine levels, and impairs seedling growth and reproduction in Arabidopsis.

Published in:

Plant Journal, 2010, v. 62, n. 6, p. 977, doi. 10.1111/j.1365-313X.2010.04211.x

By:

Bürstenbinder, Katharina;
Waduwara, Ishari;
Schoor, Sarah;
Moffatt, Barbara A.;
Wirtz, Markus;
Minocha, Subhash C.;
Oppermann, Yasmin;
Bouchereau, Alain;
Hell, Rüdiger;
Sauter, Margret

Publication type:

Article

Product inhibition in the radical S-adenosylmethionine family

Published in:

FEBS Letters, 2009, v. 583, n. 8, p. 1358, doi. 10.1016/j.febslet.2009.03.044

By:

Challand, Martin R.;
Ziegert, Tillman;
Douglas, Paul;
Wood, Robert J.;
Kriek, Marco;
Shaw, Nicholas M.;
Roach, Peter L.

Publication type:

Article

Metabolism: Nothing to waste.

Published in:

Nature Chemical Biology, 2012, v. 8, n. 11, p. 877, doi. 10.1038/nchembio.1089

By:

Atomi, Haruyuki

Publication type:

Article

Synthesis, Spectral Characterization and Analgesic Activity of 2-Methylthio-1,4-Dihydropyrimidines.

Published in:

Iranian Journal of Pharmaceutical Research, 2011, v. 10, n. 4, p. 733

By:

Sawant, Ramesh;
Sarode, Varsha

Publication type:

Article

5′-Methylthioadenosine Attenuates Ischemia Reperfusion Injury After Liver Transplantation in Rats.

Published in:

Inflammation, 2014, v. 37, n. 5, p. 1366, doi. 10.1007/s10753-014-9861-x

By:

Tang, Yong;
Zhang, Weikang;
Zhang, Yu;
Wang, Wenjing;
Yao, Feng;
Yan, Jiaqi;
Wan, Chidan

Publication type:

Article

Works matching DE "METHYLTHIOADENOSINE"

Leishmania infantum 5'-Methylthioadenosine Phosphorylase presents relevant structural divergence to constitute a potential drug target.

Transition state analogue of MTAP extends lifespan of APCMin/+ mice.

Molecular dynamics study of the effect of active site protonation on Helicobacter pylori 5′-methylthioadenosine/ S-adenosylhomocysteine nucleosidase.

Effects of S-adenosylmethionine and methylthioadenosine on inflammation-induced colon cancer in mice.

Characterization of the Methylthioadenosine Phosphorylase Polymorphism rs7023954 - Incidence and Effects on Enzymatic Function in Malignant Melanoma.

Eculizumab for the treatment of pregnancy-related atypical hemolytic uremic syndrome.

Octreotide prevents liver failure through upregulating 5′-methylthioadenosine in extended hepatectomized rats.

Synthesis of new naphthostyryl derivatives via nucleophilic substitution of methylthio group with C-nucleophiles. Molecular and crystal structure of ( Z)-2-{benzo[ cd]indol-2(1 H)-ylidene}-2-(4-phenythiazol-2-yl)acetonitrile.

Metabolic characteristics and importance of the universal methionine salvage pathway recycling methionine from 5′-methylthioadenosine.

Methylthioadenosine phosphorylase (MTAP)-deficient T-cell ALL xenografts are sensitive to pralatrexate and 6-thioguanine alone and in combination.

Structures of lipoyl synthase reveal a compact active site for controlling sequential sulfur insertion reactions.

Metabolomic and transcriptomic profiling reveals the alteration of energy metabolism in oyster larvae during initial shell formation and under experimental ocean acidification.

DRUG REPURPOSING TOWARDS THE IDENTIFICATION OF NOVEL ANTI-LEISHMANIA MOLECULES TARGETING THE METHYLTHIOADENOSINE PHOSPHORYLASE.

Simple and efficient synthesis of new N<sub>(3)</sub>-, O- and S-substituted 2-methylthio-6-phenylpyrimidin- 4(3H)-one based derivatives.

Methylthioadenosine phosphorylase inactivation depends on gene deletion in laryngeal squamous cell carcinoma.

Identification of a 2-cell stage specific inhibitor of the cleavage of preimplantation mouse embryos synthesized by rat hepatoma cells as 5′-deoxy-5′-methylthioadenosine.

Phloem-Specific Methionine Recycling Fuels Polyamine Biosynthesis in a Sulfur-DependentManner and Promotes Flower and Seed Development.

Recycling of Methylthioadenosine Is Essential for Normal Vascular Development and Reproduction in Arabidopsis.

Crystal Structure of Schistosoma mansoni Adenosine Phosphorylase/5’-Methylthioadenosine Phosphorylase and Its Importance on Adenosine Salvage Pathway.

Methylthioadenosine Reprograms Macrophage Activation through Adenosine Receptor Stimulation.

Differential Neuroprotective Effects of 5′-Deoxy-5′-Methylthioadenosine.

Expression and Function of Methylthioadenosine Phosphorylase in Chronic Liver Disease.

Germline Mutations in <i>Mtap</i> Cooperate with <i>Myc</i> to Accelerate Tumorigenesis in Mice.

A Study on the Interaction of Rhodamine B with Methylthioadenosine Phosphorylase Protein Sourced from an Antarctic Soil Metagenomic Library.

Multilevel pharmacokinetics-driven modeling of metabolomics data.

Integration of untargeted metabolomics with transcriptomics reveals active metabolic pathways.

Crystallization and preliminary X-ray diffraction analysis of the interaction of Aeromonas hydrophila MtaN-1 with S-adenosylhomocysteine.

Characterization of methylthioadenosin phosphorylase (MTAP) expression in colorectal cancer.

Inhibition of 5’-methylthioadenosine metabolism in the Yang cycle alters polyamine levels, and impairs seedling growth and reproduction in Arabidopsis.

Product inhibition in the radical S-adenosylmethionine family

Metabolism: Nothing to waste.

Synthesis, Spectral Characterization and Analgesic Activity of 2-Methylthio-1,4-Dihydropyrimidines.

5′-Methylthioadenosine Attenuates Ischemia Reperfusion Injury After Liver Transplantation in Rats.