Title: Effect of macrocyclic nickel(II) and copper(II) complexes on the reaction of trypsin with a soybean bioinhibitor.
Authors: Boltovets, P.; Tsymbal, L.; Snopok, B.; Lampeka, Ya.
Abstract: The blocking effect of nickel(II) azamacrocyclic complexes in the biospecific reaction between soybean trypsin inhibitor and trypsin and the absence of such a reaction for related copper(II) complexes were established. The efficiency for inhibition of the formation of the protein adduct was found to depend on the substituents in the macrocyclic ligands. In particular, electron-donor oxygen-containing groups lead not only to efficient blocking of this reaction but also possibly to a considerable change in the conformation of the soybean trypsin inhibitor molecule.
Subjects: PROTECTIVE groups (Chemistry); NICKEL; COPPER; TRYPSIN inhibitors; SURFACE plasmon resonance; MACROCYCLIC compounds
Publication: Theoretical & Experimental Chemistry, 2008, Vol 44, Issue 4, p260
ISSN: 0040-5760
Publication type: Academic Journal
DOI: 10.1007/s11237-008-9033-x

Effect of macrocyclic nickel(II) and copper(II) complexes on the reaction of trypsin with a soybean bioinhibitor.

Boltovets, P.; Tsymbal, L.; Snopok, B.; Lampeka, Ya.