Evolutionary computing algorithms are computational intelligent systems that are used in a wide range of research applications, primarily for optimization. In this paper, an artificial neural network (ANN), a machine learning technique, is used to classify the data. The weights associated with each neuron and the architecture of the neural network always bias the output of the network model. With prior knowledge or trial and error techniques, different metrics or objectives can be used to optimise these weights. The optimization of weights using multiple objectives refers to a "multi-objective optimization problem." In this paper, an evolutionary cultural algorithm is used to optimise weights in ANN, and the results are reported with improved accuracy. Three benchmark datasets for autism screening data are used, trained, and tested for model accuracy in the classification: toddlers (1054,19), children (292,21), and adults (704,21).With the support of the domain expert, real-time data were collected from parents and caregivers and totalled over 1000 records, with a moderate difference in attributes based on CARS-2 (Childhood Autism Rating Scale, 2nd Edition) for ASD screening. In this paper, the proposed model is compared using a curve-fitting mathematical technique. The proposed model is trained and tested, and the results showed that it outperformed other algorithms in terms of precision, accuracy, sensitivity, and specificity.