The present paper considers the conditions for the development of a large-scale karst subsidence in Moscow, which was induced, according to the specialists of Sergeev Institute of Environmental Geoscience RAS (IEG RAS), by a technogenic decrease in the groundwater level. According to the analysis of data on the structure of the soil stratum and karst rock massif, a mechanism responsible for the formation of an underground cavity at the limestone roof during sharp fluctuations in hydrogeological conditions is proposed. In addition, the paper provides an approximate estimate of both the shape and accumulating volume of the cavity, the movement of dispersed material into which leads to the subsidence of soil stratum layers. A numerical simulation study performed according to the NIIOSP method using the method of "standard curves," estimated the geometric parameters of the subsidence cavity to be close to the actual ones, recorded during its formation. The consistence between the calculated and actual results indicates the validity of the proposed scenario for subsidence development and the validity of the applied engineering calculation methodology.