Title: Creation of a Model of a Complex Delivery Nanosystem Containing a Tyrosine Kinase Inhibitor and a Photosensitizer.
Authors: Sanarova, E. V.; Lantsova, A. V.; Nikolaeva, L. L.; Oborotova, N. A.; Litvinenko, Ya. E.; Solov'eva, N. L.
Abstract: The aim of this work was to construct complex delivery systems for the well-known hydrophobic inhibitor of tyrosine kinases, Gefitinib, and the photosensitizer, aluminum phthalocyanine. The study produced two systems: the first based on soy phosphatidylcholine and surfactant and the second based on egg phosphatidylcholine, cholesterol, and PEGylated phospholipid. Both systems were evaluated in terms of particle size, æ-potential, pH, and content of active substances after production, filtration, and lyophilization. The selected optimal formulations were lyophilized and advanced to further biopharmaceutical research.
Subjects: PROTEIN-tyrosine kinase inhibitors; LECITHIN
Publication: Pharmaceutical Chemistry Journal, 2023, Vol 57, Issue 7, p1075
ISSN: 0091-150X
Publication type: Academic Journal
DOI: 10.1007/s11094-023-02986-y

Creation of a Model of a Complex Delivery Nanosystem Containing a Tyrosine Kinase Inhibitor and a Photosensitizer.

Sanarova, E. V.; Lantsova, A. V.; Nikolaeva, L. L.; Oborotova, N. A.; Litvinenko, Ya. E.; Solov'eva, N. L.