Preparation and Activity of a Complex of Oligohexamethyleneguanine with P-Aminosalicylic Acid Derivatives.

Kedik, S.; Shatalov, D.; Isaikina, P.; Askretkov, A.; Sedishev, I.; Panov, A.; Evseeva, A.

Approaches to creating complexes based on branched oligohexamethyleneguanidine hydrochloride are addressed. Novel combinations of bactericidal agents were obtained, methods for the synthesis of a series of p-aminosalicylic acid derivatives were selected, the solubilities of their complexes with oligohexamethyleneguanidine were determined, and the bactericidal activities of the resulting complexes against Mycobacterium smegmatis were assessed. The minimum inhibitory concentrations of all complexes were in the range 0.1 - 1 μg/ml of culture medium. Thus, these complexes may be useful for creating a bactericidal formulation with powerful and long-lasting biocidal action, highly reproducible properties, and low toxicity.

BACTERICIDAL action; MYCOBACTERIUM; MYCOBACTERIA; ACID derivatives; CHEMICAL derivatives

Pharmaceutical Chemistry Journal, 2017, Vol 51, Issue 9, p773

0091-150X

Academic Journal

10.1007/s11094-017-1691-3