Title: Synthesis and Antimicrobial Properties of Ammonium Salts Containing a Substituted Butyn-2-yl Group.
Authors: Manukyan, M.; Barsegyan, K.; Gyulnazaryan, A.; Paronikyan, R.; Stepanyan, G.; Minasyan, N.; Babakhanyan, A.
Abstract: Interaction of 1-dimethylamino-4-diethylaminobutyn-2, 1-dimethylamino-4-piperidinobutyn-2, and 1-dimethylamino-4-morpholinobutyn-2 with the corresponding alkyl esters of monobromo(chloro)acetic acid was used to synthesize novel monoammonium salts. Studies of the antimicrobial activity of the resulting compounds showed that salts containing hydrophobic alkoxycarbonylmethyl radicals had marked antibacterial activity against Gram-positive and Gram-negative microorganisms.
Subjects: ANTI-infective agents; GRAM-negative bacteria; ACETIC acid; FATTY acids; CHEMICAL synthesis
Publication: Pharmaceutical Chemistry Journal, 2017, Vol 51, Issue 9, p764
ISSN: 0091-150X
Publication type: Academic Journal
DOI: 10.1007/s11094-017-1689-x

Synthesis and Antimicrobial Properties of Ammonium Salts Containing a Substituted Butyn-2-yl Group.

Manukyan, M.; Barsegyan, K.; Gyulnazaryan, A.; Paronikyan, R.; Stepanyan, G.; Minasyan, N.; Babakhanyan, A.