Results
Title

Synthesis and Cytotoxic Activity of Arylsubstituted Tetrazolocyclanopyrimidines.

Authors

Vasil'kova, N.; Ivonin, M.; Burygin, G.; Prilepskii, A.; Kriven'ko, A.

Abstract

A series of arylsubstituted tetrazolocyclanodihydropyrimidines was prepared and their cytotoxic actions on SPEV-2 cells were studied. The activity of these substances was found to depend on the nature and position of the substitution groups in the benzene ring and the size of the alicycle. The most active compounds were o-chloro(methyl)phenyltetrazolohexahydroquinazolines.

Subjects

ANTINEOPLASTIC agents; BENZENE; AROMATIC compounds; SPECTRUM analysis; QUALITATIVE chemical analysis

Publication

Pharmaceutical Chemistry Journal, 2017, Vol 51, Issue 9, p756

ISSN

0091-150X

Publication type

Academic Journal

DOI

10.1007/s11094-017-1687-z