Title: Synthesis, Toxicity, and Antituberculosis Activity of Isoniazid Derivatives Containing Sterically Hindered Phenols.
Authors: Oludina, Yu.; Voloshina, A.; Kulik, M.; Zobov, V.; Bukharov, S.; Tagasheva, R.; Nugumanova, G.; Burilov, A.; Kravchenko, M.; Skornyakov, S.; Rusinov, G.
Abstract: The toxicity and tuberculostatic activity of new isoniazid derivatives containing sterically hindered phenols were investigated. The investigated isoniazid derivatives exhibited lower activity and toxicity than isoniazid.
Subjects: ANTITUBERCULAR agents; PHARMACEUTICAL chemistry; DRUG activation; ISONIAZID; CHEMICAL derivatives; PHENOLS
Publication: Pharmaceutical Chemistry Journal, 2014, Vol 48, Issue 1, p5
ISSN: 0091-150X
Publication type: Academic Journal
DOI: 10.1007/s11094-014-1032-8

Synthesis, Toxicity, and Antituberculosis Activity of Isoniazid Derivatives Containing Sterically Hindered Phenols.

Oludina, Yu.; Voloshina, A.; Kulik, M.; Zobov, V.; Bukharov, S.; Tagasheva, R.; Nugumanova, G.; Burilov, A.; Kravchenko, M.; Skornyakov, S.; Rusinov, G.