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Title

Synthesis, Toxicity, and Antituberculosis Activity of Isoniazid Derivatives Containing Sterically Hindered Phenols.

Authors

Oludina, Yu.; Voloshina, A.; Kulik, M.; Zobov, V.; Bukharov, S.; Tagasheva, R.; Nugumanova, G.; Burilov, A.; Kravchenko, M.; Skornyakov, S.; Rusinov, G.

Abstract

The toxicity and tuberculostatic activity of new isoniazid derivatives containing sterically hindered phenols were investigated. The investigated isoniazid derivatives exhibited lower activity and toxicity than isoniazid.

Subjects

ANTITUBERCULAR agents; PHARMACEUTICAL chemistry; DRUG activation; ISONIAZID; CHEMICAL derivatives; PHENOLS

Publication

Pharmaceutical Chemistry Journal, 2014, Vol 48, Issue 1, p5

ISSN

0091-150X

Publication type

Academic Journal

DOI

10.1007/s11094-014-1032-8

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