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- Title
Quality of liposomal phospholipids at different stages in the manufacturing process.
- Authors
Sanarova, E.; Kotova, E.; Kozeev, S.; Lantsova, A.; Polozkova, A.; Krasnyuk, I.; Oborotova, N.
- Abstract
We report here studies of the effects of liposome preparation methods on measures of the quality of phosphatidylcholine used, this being the main component of the liposomal bilayer and extremely unstable to the temperatures of manufacturing processes containing oxygen and transition metal ions. One process destructive for this phospholipid is peroxidation, the level of which is generally assessed in terms of the malondialdehyde concentration and the Klein oxidation index. Extrusion and homogenization of large multilamellar liposomes were found to be the least damaging methods of preparing liposomes, as compared with sonication. Attempts to introduce an antioxidant (vitamin E) did not lead to any significant improvement in the parameters assessed.
- Subjects
PHOSPHOLIPIDS; MANUFACTURING processes; LECITHIN; ANTIOXIDANTS; PARAMETER estimation; LIPOSOMES
- Publication
Pharmaceutical Chemistry Journal, 2012, Vol 46, Issue 3, p192
- ISSN
0091-150X
- Publication type
Academic Journal
- DOI
10.1007/s11094-012-0758-4