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Title: Synthesis and pharmacological activity of ω-(4-phenylpiperazin-1-yl)alkylthiopyrimidines.
Authors: Reznik, V.; Pashkurov, N.; Mikhailov, A.; Akamsin, V.; Galyametdinova, I.; Zobov, V.; Lantsova, A.
Abstract: The article cites a study which focused on the synthesis and pharmacological activity of &b.omega;-(4-phenylpiperazin-1-yl) alkylthiopyrimidines. The researchers synthesized and characterized a series of N-phenylpiperazine derivatives containing a mercaptopyrimidine cycle, which plays the role of a fragment favoring an increase in the affinity of compounds to adrenoreceptors of blood vessels. The synthesized &b.omega;-(4-phenylpiperazin-1-yl) alkylthiopyrimidines possess hypotensive activity, which can be related to their interaction with alpha adrenoreceptors of peripheral blood vessels.
Subjects: PYRIMIDINES; THIOLS; ALPHA adrenoceptors; BLOOD vessels; HETEROCYCLIC compounds; ADRENERGIC receptors
Publication: Pharmaceutical Chemistry Journal, 2004, Vol 38, Issue 12, p654
ISSN: 0091-150X
Publication type: Academic Journal
DOI: 10.1007/s11094-005-0053-8

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Synthesis and pharmacological activity of ω-(4-phenylpiperazin-1-yl)alkylthiopyrimidines.