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- Title
Monoamines as Adaptive Regulators of Development: The Phenomenon and Its Mechanisms of Action.
- Authors
Voronezhskaya, E. E.; Melnikova, V. I.; Ivashkin, E. G.
- Abstract
A significant number of integrative functions in the body are mediated by the monoaminergic systems: a set of low molecular weight transmitters which are biogenic amines (serotonin and dopamine), the enzymes of their metabolism, and their receptors. This makes monoamines a major component of the nervous and endocrine systems in the body, determining the adaptogenic capabilities of the body in continually changing environmental conditions. Using our own experimental material as an example, along with published data, we discuss the regulatory role of monoamines in development, starting with the oocyte and early cleavage stage and extending to formation of the neural networks underlying behavior. The classical ligand-receptor mechanism is considered, along with the mechanism of noncanonical modification of intracellular proteins (monoaminylation) and their contribution to adaptive regulation at different stages of development. The role of monoamines as a conservative factor binding environmental signals and the physiology of the developing body is discussed.
- Subjects
ECOPHYSIOLOGY; ENZYME metabolism; BIOGENIC amines; NERVOUS system; ENDOCRINE system
- Publication
Neuroscience & Behavioral Physiology, 2021, Vol 51, Issue 9, p1278
- ISSN
0097-0549
- Publication type
Academic Journal
- DOI
10.1007/s11055-021-01191-2