Title: Immobilization of carborane derivatives on Ni/Fe nanotubes for BNCT.
Authors: Korolkov, Ilya V.; Kozlovskiy, Artem L.; Gorin, Yevgeniy G.; Kazantsev, Aleksander V.; Shlimas, Dmitriy I.; Zdorovets, Maxim V.; Ualieva, Nazerke K.; Rusakov, Viacheslav S.
Abstract: The most important limitation for boron neutron capture therapy of cancer is the selective accumulation of boron compounds in tumor tissues in significant quantities. In this paper, we describe the possibility to use magnetic Ni/Fe nanotubes as carriers for boron delivery. Carborane derivatives containing 10 and 21 boron atoms per molecule were immobilized on Ni/Fe nanotubes by covalent and ionic interactions. Magnetic properties of NTs were investigated by Mössbauer spectroscopy. Structure, element, chemical composition, and morphology of obtained magnetic nanotubes were studied by XRD, SEM-EDA, and FTIR spectroscopy. Results indicate success immobilization of carborane derivatives on Ni/Fe nanotubes and great potential to use them as carriers for boron neutron cancer therapy of cancer.ᅟ
Subjects: CARBORANES; NICKEL alloys; BORON-neutron capture therapy; CANCER treatment; NANOTUBES
Publication: Journal of Nanoparticle Research, 2018, Vol 20, Issue 9, p1
ISSN: 1388-0764
Publication type: Academic Journal
DOI: 10.1007/s11051-018-4346-8

Immobilization of carborane derivatives on Ni/Fe nanotubes for BNCT.

Korolkov, Ilya V.; Kozlovskiy, Artem L.; Gorin, Yevgeniy G.; Kazantsev, Aleksander V.; Shlimas, Dmitriy I.; Zdorovets, Maxim V.; Ualieva, Nazerke K.; Rusakov, Viacheslav S.